Literature DB >> 17496077

Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae.

Alexandra Friedrich1, Cindy G Arvidson, William M Shafer, Eun-Hee Lee, Magdalene So.   

Abstract

Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

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Year:  2007        PMID： 17496077      PMCID： PMC1951848          DOI： 10.1128/JB.00300-07

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  36 in total

Review 1.  Type IV pili and cell motility.

Authors:  D Wall; D Kaiser
Journal:  Mol Microbiol       Date:  1999-04       Impact factor: 3.501

2.  Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species.

Authors:  Richard A Stabler; Gemma L Marsden; Adam A Witney; Yanwen Li; Stephen D Bentley; Christoph M Tang; Jason Hinds
Journal:  Microbiology       Date:  2005-09       Impact factor: 2.777

3.  RpoH mediates the expression of some, but not all, genes induced in Neisseria gonorrhoeae adherent to epithelial cells.

Authors:  Ying Du; Cindy Grove Arvidson
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

4.  The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells.

Authors:  Patricia Ayala; J Scott Wilbur; Lee M Wetzler; John A Tainer; Aurelie Snyder; Magdalene So
Journal:  Cell Microbiol       Date:  2005-12       Impact factor: 3.715

5.  Global gene expression and the role of sigma factors in Neisseria gonorrhoeae in interactions with epithelial cells.

Authors:  Ying Du; Jonathan Lenz; Cindy Grove Arvidson
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

6.  PilT is required for PI(3,4,5)P3-mediated crosstalk between Neisseria gonorrhoeae and epithelial cells.

Authors:  Shaun W Lee; Dustin L Higashi; Aurelie Snyder; Alexey J Merz; Laura Potter; Magdalene So
Journal:  Cell Microbiol       Date:  2005-09       Impact factor: 3.715

7.  Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells.

Authors:  A J Merz; C A Enns; M So
Journal:  Mol Microbiol       Date:  1999-06       Impact factor: 3.501

8.  The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids.

Authors:  E H Lee; W M Shafer
Journal:  Mol Microbiol       Date:  1999-08       Impact factor: 3.501

9.  Neisseria gonorrhoeae mutants altered in toxicity to human fallopian tubes and molecular characterization of the genetic locus involved.

Authors:  C G Arvidson; R Kirkpatrick; M T Witkamp; J A Larson; C A Schipper; L S Waldbeser; P O'Gaora; M Cooper; M So
Journal:  Infect Immun       Date:  1999-02       Impact factor: 3.441

10.  The N. gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism.

Authors:  Heather L Howie; Michael Glogauer; Magdalene So
Journal:  PLoS Biol       Date:  2005-03-22       Impact factor: 8.029
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  7 in total

Review 1.  MarR family proteins are important regulators of clinically relevant antibiotic resistance.

Authors:  Grace A Beggs; Richard G Brennan; Mehreen Arshad
Journal:  Protein Sci       Date:  2019-11-14       Impact factor: 6.725

2.  The Neisseria gonorrhoeae type IV pilus promotes resistance to hydrogen peroxide- and LL-37-mediated killing by modulating the availability of intracellular, labile iron.

Authors:  Linda I Hu; Elizabeth A Stohl; H Steven Seifert
Journal:  PLoS Pathog       Date:  2022-06-17       Impact factor: 7.464

3.  Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins.

Authors:  Jocelyn C Ray; Asya Smirnov; Stavros A Maurakis; Simone A Harrison; Eugene Ke; Walter J Chazin; Cynthia Nau Cornelissen; Alison K Criss
Journal:  Infect Immun       Date:  2022-01-18       Impact factor: 3.609

4.  Pilin regulation in the pilT mutant of Neisseria gonorrhoeae strain MS11.

Authors:  Manuela Dietrich; Hans Mollenkopf; Magdalene So; Alexandra Friedrich
Journal:  FEMS Microbiol Lett       Date:  2009-05-08       Impact factor: 2.742

5.  Twitching motility is essential for virulence in Dichelobacter nodosus.

Authors:  Xiaoyan Han; Ruth M Kennan; John K Davies; Leslie A Reddacliff; Om P Dhungyel; Richard J Whittington; Lynne Turnbull; Cynthia B Whitchurch; Julian I Rood
Journal:  J Bacteriol       Date:  2008-02-29       Impact factor: 3.490

6.  Upregulation of ATF3 inhibits expression of the pro-inflammatory cytokine IL-6 during Neisseria gonorrhoeae infection.

Authors:  Christine M Calton; Laura K Wade; Magdalene So
Journal:  Cell Microbiol       Date:  2013-05-23       Impact factor: 3.715

7.  Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae.

Authors:  Vincent M Isabella; Virginia L Clark
Journal:  BMC Genomics       Date:  2011-01-20       Impact factor: 3.969
  7 in total

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