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Literature DB >> 17483800

Identification and characterization of the Vibrio vulnificus rtxA essential for cytotoxicity in vitro and virulence in mice.

Jeong Hyun Lee¹, Myung Won Kim, Byoung Sik Kim, Seung Min Kim, Byung Cheol Lee, Tae Sung Kim, Sang Ho Choi.

Abstract

A mutant exhibiting decreased cytotoxic activity toward INT-407 intestinal epithelial cells and carrying a mutation in the rtx gene cluster that consists of rtxCA and rtxBDE operons was screened from a library of V. vulnificus mutants. The functions of the rtxA gene, assessed by constructing an isogenic mutant and evaluating its phenotypic changes, demonstrated that RtxA is essential for the virulence of V. vulnificus in mice as well as in tissue cultures.

Entities: Disease Gene Species

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Year: 2007 PMID： 17483800

Source DB: PubMed Journal: J Microbiol ISSN： 1225-8873 Impact factor: 3.422

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Cited

79 in total

1. VvpM, an extracellular metalloprotease of Vibrio vulnificus, induces apoptotic death of human cells.

Authors: Mi-Ae Lee; Jeong-A Kim; Yu Jin Yang; Mee-Young Shin; Soon-Jung Park; Kyu-Ho Lee
Journal: J Microbiol Date: 2014-11-03 Impact factor: 3.422

Review 2. Allosteric regulation of protease activity by small molecules.

Authors: Aimee Shen
Journal: Mol Biosyst Date: 2010-06-10

3. Homodimerization and binding of specific domains to the target DNA are essential requirements for HlyU to regulate expression of the virulence gene rtxA1, encoding the repeat-in-toxin protein in the human pathogen Vibrio vulnificus.

Authors: Moqing Liu; Michael Rose; Jorge H Crosa
Journal: J Bacteriol Date: 2011-10-21 Impact factor: 3.490

4. Cooperative regulation of the Vibrio vulnificus nan gene cluster by NanR protein, cAMP receptor protein, and N-acetylmannosamine 6-phosphate.

Authors: Byoung Sik Kim; Jungwon Hwang; Myung Hee Kim; Sang Ho Choi
Journal: J Biol Chem Date: 2011-09-28 Impact factor: 5.157

5. Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus.

Authors: Francisco J Roig; Fernando González-Candelas; Carmen Amaro
Journal: Appl Environ Microbiol Date: 2010-11-12 Impact factor: 4.792

Identification and characterization of the Vibrio vulnificus rtxA essential for cytotoxicity in vitro and virulence in mice.

1. VvpM, an extracellular metalloprotease of Vibrio vulnificus, induces apoptotic death of human cells.

Review 2. Allosteric regulation of protease activity by small molecules.

3. Homodimerization and binding of specific domains to the target DNA are essential requirements for HlyU to regulate expression of the virulence gene rtxA1, encoding the repeat-in-toxin protein in the human pathogen Vibrio vulnificus.

4. Cooperative regulation of the Vibrio vulnificus nan gene cluster by NanR protein, cAMP receptor protein, and N-acetylmannosamine 6-phosphate.

5. Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus.

6. Monoclonal antibodies against Vibrio vulnificus RtxA1 elicit protective immunity through distinct mechanisms.

Review 7. MARTX, multifunctional autoprocessing repeats-in-toxin toxins.

Review 8. Vibrio vulnificus: disease and pathogenesis.

9. Vibrio vulnificus bacteriophage SSP002 as a possible biocontrol agent.

10. A common virulence plasmid in biotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid.