Literature DB >> 17483256

Pichia acaciae killer system: genetic analysis of toxin immunity.

John P Paluszynski1, Roland Klassen, Friedhelm Meinhardt.   

Abstract

The gene responsible for self-protection in the Pichia acaciae killer plasmid system was identified by heterologous expression in Saccharomyces cerevisiae. Resistance profiling and conditional toxin/immunity coexpression analysis revealed dose-independent protection by pPac1-2 ORF4 and intracellular interference with toxin function, suggesting toxin reinternalization in immune killer cells.

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Year:  2007        PMID： 17483256      PMCID： PMC1932769          DOI： 10.1128/AEM.00271-07

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  36 in total

1.  Heterologous gene expression on the linear DNA killer plasmid from Kluyveromyces lactis.

Authors:  J Kämper; K Esser; N Gunge; F Meinhardt
Journal:  Curr Genet       Date:  1991-02       Impact factor: 3.886

Review 2.  The plasmid-encoded killer system of Kluyveromyces lactis: a review.

Authors:  M J Stark; A Boyd; A J Mileham; M A Romanos
Journal:  Yeast       Date:  1990 Jan-Feb       Impact factor: 3.239

3.  New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.

Authors:  R D Gietz; A Sugino
Journal:  Gene       Date:  1988-12-30       Impact factor: 3.688

4.  Killer toxin production in Pichia acaciae is associated with linear DNA plasmids.

Authors:  P L Worsham; P L Bolen
Journal:  Curr Genet       Date:  1990-07       Impact factor: 3.886

5.  Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae.

Authors:  John P Paluszynski; Roland Klassen; Matthias Rohe; Friedhelm Meinhardt
Journal:  Yeast       Date:  2006-07-15       Impact factor: 3.239

6.  The linear-plasmid-encoded toxin produced by the yeast Pichia acaciae: characterization and comparison with the toxin of Kluyveromyces lactis.

Authors:  D A McCracken; V J Martin; M J Stark; P L Bolen
Journal:  Microbiology       Date:  1994-02       Impact factor: 2.777

7.  Linear DNA plasmids of Pichia inositovora are associated with a novel killer toxin activity.

Authors:  G T Hayman; P L Bolen
Journal:  Curr Genet       Date:  1991-05       Impact factor: 3.886

8.  Isolation and sequence analysis of a gene from the linear DNA plasmid pPacl-2 of Pichia acaciae that shows similarity to a killer toxin gene of Kluyveromyces lactis.

Authors:  P L Bolen; E M Eastman; P L Cihak; G T Hayman
Journal:  Yeast       Date:  1994-03       Impact factor: 3.239

9.  Expression of pGKL killer 28K subunit in Saccharomyces cerevisiae: identification of 28K subunit as a killer protein.

Authors:  M Tokunaga; A Kawamura; F Hishinuma
Journal:  Nucleic Acids Res       Date:  1989-05-11       Impact factor: 16.971

10.  The killer toxin of Kluyveromyces lactis: characterization of the toxin subunits and identification of the genes which encode them.

Authors:  M J Stark; A Boyd
Journal:  EMBO J       Date:  1986-08       Impact factor: 11.598
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  7 in total

1.  Site-directed mutagenesis of the heterotrimeric killer toxin zymocin identifies residues required for early steps in toxin action.

Authors:  Sabrina Wemhoff; Roland Klassen; Friedhelm Meinhardt
Journal:  Appl Environ Microbiol       Date:  2014-08-15       Impact factor: 4.792

2.  Evolutionary capture of viral and plasmid DNA by yeast nuclear chromosomes.

Authors:  A Carolin Frank; Kenneth H Wolfe
Journal:  Eukaryot Cell       Date:  2009-08-07

3.  Immunity factors for two related tRNAGln targeting killer toxins distinguish cognate and non-cognate toxic subunits.

Authors:  Roland Klassen; Alene Kast; Guido Wünsche; John P Paluszynski; Sabrina Wemhoff; Friedhelm Meinhardt
Journal:  Curr Genet       Date:  2014-04-10       Impact factor: 3.886

4.  Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination.

Authors:  Anupam K Chakravarty; Paul Smith; Radhika Jalan; Stewart Shuman
Journal:  Cell Rep       Date:  2014-04-13       Impact factor: 9.423

5.  Autoselection of cytoplasmic yeast virus like elements encoding toxin/antitoxin systems involves a nuclear barrier for immunity gene expression.

Authors:  Alene Kast; Raphael Voges; Michael Schroth; Raffael Schaffrath; Roland Klassen; Friedhelm Meinhardt
Journal:  PLoS Genet       Date:  2015-05-14       Impact factor: 5.917

6.  Yeast killer elements hold their hosts hostage.

Authors:  Reed B Wickner; Herman K Edskes
Journal:  PLoS Genet       Date:  2015-05-14       Impact factor: 5.917

7.  DNA Damage Responses Are Induced by tRNA Anticodon Nucleases and Hygromycin B.

Authors:  Sabrina Wemhoff; Roland Klassen; Anja Beetz; Friedhelm Meinhardt
Journal:  PLoS One       Date:  2016-07-29       Impact factor: 3.240
  7 in total

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