Literature DB >> 17482816

A novel artemisinin-quinine hybrid with potent antimalarial activity.

John J Walsh1, David Coughlan, Nicola Heneghan, Caroline Gaynor, Angus Bell.   

Abstract

Artemisinin was reduced to dihydroartemisinin and coupled to a carboxylic acid derivative of quinine via an ester linkage. This novel hybrid molecule had potent activity against the 3D7 and (drug-resistant) FcB1 strains of Plasmodium falciparum in culture. The activity was superior to that of artemisinin alone, quinine alone, or a 1:1 mixture of artemisinin and quinine.

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Year:  2007        PMID： 17482816     DOI： 10.1016/j.bmcl.2007.04.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  29 in total

Review 1.  Plant-derived natural product research aimed at new drug discovery.

Authors:  Hideji Itokawa; Susan L Morris-Natschke; Toshiyuki Akiyama; Kuo-Hsiung Lee
Journal:  J Nat Med       Date:  2008-04-22       Impact factor: 2.343

Review 2.  Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Authors:  Drishti Agarwal; Rinkoo D Gupta; Satish K Awasthi
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

3.  3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents.

Authors:  Charles E Schiaffo; Matthias Rottman; Sergio Wittlin; Patrick H Dussault
Journal:  ACS Med Chem Lett       Date:  2011-04-14       Impact factor: 4.345

4.  Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy.

Authors:  Rita Capela; Ghislain G Cabal; Philip J Rosenthal; Jiri Gut; Maria M Mota; Rui Moreira; Francisca Lopes; Miguel Prudêncio
Journal:  Antimicrob Agents Chemother       Date:  2011-08-01       Impact factor: 5.191

5.  Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.

Authors:  Theresa Dinio; Alexander P Gorka; Andrew McGinniss; Paul D Roepe; Jeremy B Morgan
Journal:  Bioorg Med Chem       Date:  2012-03-29       Impact factor: 3.641

6.  Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds.

Authors:  Aicha Boudhar; Xiao Wei Ng; Chiew Yee Loh; Wan Ni Chia; Zhi Ming Tan; Francois Nosten; Brian W Dymock; Kevin S W Tan
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

7.  Novel tetracyclic structures from the synthesis of thiolactone-isatin hybrids.

Authors:  Renate Hazel Hans; Hong Su; Kelly Chibale
Journal:  Beilstein J Org Chem       Date:  2010-07-19       Impact factor: 2.883

8.  Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites.

Authors:  Sanna R Rijpma; Maarten van der Velden; Maria González-Pons; Takeshi Annoura; Ben C L van Schaijk; Geert-Jan van Gemert; Jeroen J M W van den Heuvel; Jai Ramesar; Severine Chevalley-Maurel; Ivo H Ploemen; Shahid M Khan; Jean-Francois Franetich; Dominique Mazier; Johannes H W de Wilt; Adelfa E Serrano; Frans G M Russel; Chris J Janse; Robert W Sauerwein; Jan B Koenderink; Blandine M Franke-Fayard
Journal:  Cell Microbiol       Date:  2015-11-10       Impact factor: 3.715

9.  Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.

Authors:  Rita Capela; Rudi Oliveira; Lídia M Gonçalves; Ana Domingos; Jiri Gut; Philip J Rosenthal; Francisca Lopes; Rui Moreira
Journal:  Bioorg Med Chem Lett       Date:  2009-05-03       Impact factor: 2.823

Review 10.  Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

Authors:  Timothy W Corson; Nicholas Aberle; Craig M Crews
Journal:  ACS Chem Biol       Date:  2008-11-21       Impact factor: 5.100
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