Literature DB >> 17482610

DNA mismatch repair gene hMLH3 variants in meiotic arrest.

Cristina Ferrás1, Xiao-lei Zhou, Mário Sousa, Annika Lindblom, Alberto Barros.   

Abstract

Defects of the DNA mismatch repair gene hMLH3 were screened by denaturing high-performance liquid chromatography and sequencing in germinal tissue DNA from patients with spermatogenic arrest, with sequence variations being confirmed in genomic DNA by polymerase chain reaction (PCR) direct sequencing analysis. Four missense (2896T/C, 2531C/T) and eight intronic (IVS9+66G/A) variants were found, with the combination of 2531C/T and IVS9+66G/A being identified only in patients with primary meiotic arrest, thus suggesting that two simultaneous hMLH3 variants might predispose to spermatogenic arrest.

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Year:  2007        PMID： 17482610     DOI： 10.1016/j.fertnstert.2007.01.063

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  6 in total

1.  Single-nucleotide polymorphism rs 175080 in the MLH3 gene and its relation to male infertility.

Authors:  Ourania Markandona; Konstantinos Dafopoulos; George Anifandis; Christina I Messini; Marina Dimitraki; Aspasia Tsezou; Panagiotis Georgoulias; Ioannis E Messinis
Journal:  J Assist Reprod Genet       Date:  2015-10-31       Impact factor: 3.412

2.  Analysis of microRNA expression in the prepubertal testis.

Authors:  Gregory M Buchold; Cristian Coarfa; Jong Kim; Aleksandar Milosavljevic; Preethi H Gunaratne; Martin M Matzuk
Journal:  PLoS One       Date:  2010-12-29       Impact factor: 3.240

Review 3.  Impact of DNA mismatch repair system alterations on human fertility and related treatments.

Authors:  Min-hao Hu; Shu-yuan Liu; Ning Wang; Yan Wu; Fan Jin
Journal:  J Zhejiang Univ Sci B       Date:  2016-01       Impact factor: 3.066

4.  Analysis of MLH3 C2531T polymorphism in Iranian women with unexplained infertility.

Authors:  Hossein Pashaiefar; Mohammad Hasan Sheikhha; Seyyed Mehdi Kalantar; Tahereh Jahaninejad; Mohammad Ali Zaimy; Nasrin Ghasemi
Journal:  Iran J Reprod Med       Date:  2013-01

5.  Embryological Results of Couples Undergoing ICSI-ET Treatments with Males Carrying the Single Nucleotide Polymorphism rs175080 of the MLH3 Gene.

Authors:  George Anifandis; Ourania Markandona; Konstantinos Dafopoulos; Christina Messini; Aspasia Tsezou; Marina Dimitraki; Panagiotis Georgoulias; Alexandros Daponte; Ioannis Messinis
Journal:  Int J Mol Sci       Date:  2017-02-02       Impact factor: 5.923

6.  A Catalog of Human Genes Associated With Pathozoospermia and Functional Characteristics of These Genes.

Authors:  Elena V Ignatieva; Alexander V Osadchuk; Maxim A Kleshchev; Anton G Bogomolov; Ludmila V Osadchuk
Journal:  Front Genet       Date:  2021-07-05       Impact factor: 4.599
  6 in total

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