PURPOSE: The purpose of the study was to evaluate the neuropsychological effects of ciguatera fish poisoning (CFP). METHOD: In a longitudinal matched cohort study, 12 CFP cases and 12 matched friend-controls received baseline neuropsychological evaluations within one month after intoxication and follow-up evaluations approximately six months after baseline. RESULTS: Only one case received intravenous mannitol treatment, which occurred 10 or more days after intoxication. At baseline and follow-up evaluations, there were no statistically significant differences between CFP cases and controls on cognitive measures. At baseline, however, CFP cases endorsed significantly greater subjective toxicity symptoms (e.g. fatigue, tingling sensations) and greater anxiety symptoms than controls. Follow-up evaluations suggested resolution of all symptoms after six months. Subsequent analyses, in which data from this study were pooled with data from an earlier pilot study, supported these results. CONCLUSION: Untreated ciguatera was associated acutely with significant subjective neurotoxicity symptoms and anxiety which were transient, but not with objectively measured cognitive changes. Future investigation with a larger sample size is warranted.
PURPOSE: The purpose of the study was to evaluate the neuropsychological effects of ciguatera fish poisoning (CFP). METHOD: In a longitudinal matched cohort study, 12 CFP cases and 12 matched friend-controls received baseline neuropsychological evaluations within one month after intoxication and follow-up evaluations approximately six months after baseline. RESULTS: Only one case received intravenous mannitol treatment, which occurred 10 or more days after intoxication. At baseline and follow-up evaluations, there were no statistically significant differences between CFP cases and controls on cognitive measures. At baseline, however, CFP cases endorsed significantly greater subjective toxicity symptoms (e.g. fatigue, tingling sensations) and greater anxiety symptoms than controls. Follow-up evaluations suggested resolution of all symptoms after six months. Subsequent analyses, in which data from this study were pooled with data from an earlier pilot study, supported these results. CONCLUSION: Untreated ciguatera was associated acutely with significant subjective neurotoxicity symptoms and anxiety which were transient, but not with objectively measured cognitive changes. Future investigation with a larger sample size is warranted.
Authors: Gajendra Kumar; Ngan Pan Bennett Au; Elva Ngai Yu Lei; Yim Ling Mak; Leanne Lai Hang Chan; Michael Hon Wah Lam; Leo Lai Chan; Paul Kwan Sing Lam; Chi Him Eddie Ma Journal: Mol Neurobiol Date: 2016-09-10 Impact factor: 5.590
Authors: Melissa A Friedman; Mercedes Fernandez; Lorraine C Backer; Robert W Dickey; Jeffrey Bernstein; Kathleen Schrank; Steven Kibler; Wendy Stephan; Matthew O Gribble; Paul Bienfang; Robert E Bowen; Stacey Degrasse; Harold A Flores Quintana; Christopher R Loeffler; Richard Weisman; Donna Blythe; Elisa Berdalet; Ram Ayyar; Danielle Clarkson-Townsend; Karen Swajian; Ronald Benner; Tom Brewer; Lora E Fleming Journal: Mar Drugs Date: 2017-03-14 Impact factor: 5.118
Authors: Melissa A Friedman; Lora E Fleming; Mercedes Fernandez; Paul Bienfang; Kathleen Schrank; Robert Dickey; Marie-Yasmine Bottein; Lorraine Backer; Ram Ayyar; Richard Weisman; Sharon Watkins; Ray Granade; Andrew Reich Journal: Mar Drugs Date: 2008-08-21 Impact factor: 5.118