| Literature DB >> 17475489 |
Gui-Bai Liang1, Xiaoxia Qian, Dennis Feng, Michael Fisher, Christine M Brown, Anne Gurnett, Penny Sue Leavitt, Paul A Liberator, Andrew S Misura, Tamas Tamas, Dennis M Schmatz, Matthew Wyvratt, Tesfaye Biftu.
Abstract
Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.Entities:
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Year: 2007 PMID： 17475489 DOI： 10.1016/j.bmcl.2007.04.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823