Literature DB >> 17475214

PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.

Zhenqi Zhu1, Xin He, Carla Johnson, John Stoops, Amanda E Eaker, David S Stoffer, Aaron Bell, Reza Zarnegar, Marie C DeFrances.   

Abstract

Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator.

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Year:  2007        PMID： 17475214      PMCID： PMC1978172          DOI： 10.1016/j.bbrc.2007.04.096

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

Review 1.  The phosphoinositide 3-kinase pathway.

Authors:  Lewis C Cantley
Journal:  Science       Date:  2002-05-31       Impact factor: 47.728

2.  SMART 4.0: towards genomic data integration.

Authors:  Ivica Letunic; Richard R Copley; Steffen Schmidt; Francesca D Ciccarelli; Tobias Doerks; Jörg Schultz; Chris P Ponting; Peer Bork
Journal:  Nucleic Acids Res       Date:  2004-01-01       Impact factor: 16.971

3.  Multiple sequence alignment with the Clustal series of programs.

Authors:  Ramu Chenna; Hideaki Sugawara; Tadashi Koike; Rodrigo Lopez; Toby J Gibson; Desmond G Higgins; Julie D Thompson
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

4.  Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns.

Authors:  M J Fry; G Panayotou; R Dhand; F Ruiz-Larrea; I Gout; O Nguyen; S A Courtneidge; M D Waterfield
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

5.  The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch.

Authors:  Zheng Fu; Eliah Aronoff-Spencer; Haiyan Wu; Gary J Gerfen; Jonathan M Backer
Journal:  Arch Biochem Biophys       Date:  2004-12-15       Impact factor: 4.013

6.  PIK3CA as an oncogene in cervical cancer.

Authors:  Y Y Ma; S J Wei; Y C Lin; J C Lung; T C Chang; J Whang-Peng; J M Liu; D M Yang; W K Yang; C Y Shen
Journal:  Oncogene       Date:  2000-05-25       Impact factor: 9.867

7.  A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.

Authors:  A Klippel; J A Escobedo; Q Hu; L T Williams
Journal:  Mol Cell Biol       Date:  1993-09       Impact factor: 4.272

8.  PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway.

Authors:  X Wan; Y Yokoyama; A Shinohara; Y Takahashi; T Tamaya
Journal:  Cell Death Differ       Date:  2002-04       Impact factor: 15.828

9.  PI 3-kinase: structural and functional analysis of intersubunit interactions.

Authors:  R Dhand; K Hara; I Hiles; B Bax; I Gout; G Panayotou; M J Fry; K Yonezawa; M Kasuga; M D Waterfield
Journal:  EMBO J       Date:  1994-02-01       Impact factor: 11.598

Review 10.  Phosphoinositide 3-kinase signalling pathways.

Authors:  D A Cantrell
Journal:  J Cell Sci       Date:  2001-04       Impact factor: 5.285
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  40 in total

1.  A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1.

Authors:  Shaurya Joshi; Jianqin Wei; Nanette H Bishopric
Journal:  Biochim Biophys Acta       Date:  2015-12-02

2.  PIK3IP1 Promotes Extrafollicular Class Switching in T-Dependent Immune Responses.

Authors:  Kristina Ottens; Jalyn Schneider; Lawrence P Kane; Anne B Satterthwaite
Journal:  J Immunol       Date:  2020-09-04       Impact factor: 5.422

3.  Inhibition of T-cell activation by PIK3IP1.

Authors:  Marie C DeFrances; Daniel R Debelius; Jing Cheng; Lawrence P Kane
Journal:  Eur J Immunol       Date:  2012-07-19       Impact factor: 5.532

4.  Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.

Authors:  Xiju He; Shoutian Li; Benju Liu; Sebastian Susperreguy; Karina Formoso; Jinghong Yao; Jinsong Kang; Anbing Shi; Lutz Birnbaumer; Yanhong Liao
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-19       Impact factor: 11.205

5.  Identification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes.

Authors:  Shahanawaz Jiwani; Yi Wang; Georgina C Dowd; Antonella Gianfelice; Phannipha Pichestapong; Balramakrishna Gavicherla; Neyda Vanbennekom; Keith Ireton
Journal:  Infect Immun       Date:  2011-12-12       Impact factor: 3.441

6.  Distinct gene expression profiles characterize cellular responses to palmitate and oleate.

Authors:  Swapan K Das; Ashis K Mondal; Steven C Elbein
Journal:  J Lipid Res       Date:  2010-04-20       Impact factor: 5.922

7.  Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.

Authors:  David Chiron; Maurizio Di Liberto; Peter Martin; Xiangao Huang; Jeff Sharman; Pedro Blecua; Susan Mathew; Priyanka Vijay; Ken Eng; Siraj Ali; Amy Johnson; Betty Chang; Scott Ely; Olivier Elemento; Christopher E Mason; John P Leonard; Selina Chen-Kiang
Journal:  Cancer Discov       Date:  2014-07-31       Impact factor: 39.397

8.  PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma.

Authors:  Xin He; Zhenqi Zhu; Carla Johnson; John Stoops; Amanda E Eaker; William Bowen; Marie C DeFrances
Journal:  Cancer Res       Date:  2008-07-15       Impact factor: 12.701

9.  Cutting Edge: Foxp1 Controls Naive CD8+ T Cell Quiescence by Simultaneously Repressing Key Pathways in Cellular Metabolism and Cell Cycle Progression.

Authors:  Hairong Wei; Jianlin Geng; Bi Shi; Zhenghui Liu; Yin-Hu Wang; Anna C Stevens; Stephanie L Sprout; Min Yao; Haikun Wang; Hui Hu
Journal:  J Immunol       Date:  2016-03-21       Impact factor: 5.422

10.  The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.

Authors:  Wilson Castro; Sonia T Chelbi; Charlène Niogret; Cristina Ramon-Barros; Suzanne P M Welten; Kevin Osterheld; Haiping Wang; Giorgia Rota; Leonor Morgado; Eric Vivier; Miro E Raeber; Onur Boyman; Mauro Delorenzi; David Barras; Ping-Chih Ho; Annette Oxenius; Greta Guarda
Journal:  Nat Immunol       Date:  2018-07-02       Impact factor: 25.606
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