| Literature DB >> 17473831 |
Andres Ingason1, Thordur Sigmundsson, Stacy Steinberg, Engilbert Sigurdsson, Magnus Haraldsson, Brynja B Magnusdottir, Michael L Frigge, Augustine Kong, Jeffrey Gulcher, Unnur Thorsteinsdottir, Kari Stefansson, Hannes Petursson, Hreinn Stefansson.
Abstract
Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1,504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17473831 DOI： 10.1038/sj.ejhg.5201848
Source DB: PubMed Journal: Eur J Hum Genet ISSN： 1018-4813 Impact factor: 4.246