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Literature DB >> 20071346

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.

Andrés Ingason¹, Ina Giegling, Sven Cichon, Thomas Hansen, Henrik B Rasmussen, Jimmi Nielsen, Gesche Jürgens, Pierandrea Muglia, Annette M Hartmann, Eric Strengman, Catalina Vasilescu, Thomas W Mühleisen, Srdjan Djurovic, Ingrid Melle, Bernard Lerer, Hans-Jürgen Möller, Clyde Francks, Olli P H Pietiläinen, Jouko Lonnqvist, Jaana Suvisaari, Annamari Tuulio-Henriksson, Muriel Walshe, Evangelos Vassos, Marta Di Forti, Robin Murray, Chiara Bonetto, Sarah Tosato, Rita M Cantor, Marcella Rietschel, Nick Craddock, Michael J Owen, Leena Peltonen, Ole A Andreassen, Markus M Nöthen, David St Clair, Roel A Ophoff, Michael C O'Donovan, David A Collier, Thomas Werge, Dan Rujescu.

Abstract

The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

Entities: Disease Gene Mutation Species

Mesh：

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Year: 2010 PMID： 20071346 PMCID： PMC2838541 DOI： 10.1093/hmg/ddq009

Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150

45 in total

1. Evidence for an interaction of schizophrenia susceptibility loci on chromosome 6q23.3 and 10q24.33-q26.13 in Arab Israeli families.

Authors: A Alkelai; Y Kohn; T Olender; K Sarner-Kanyas; A Rigbi; A Hamdan; E Ben-Asher; D Lancet; B Lerer
Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2009-10-05 Impact factor: 3.568

2. Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III.

Authors: D F Levinson; P Holmans; R E Straub; M J Owen; D B Wildenauer; P V Gejman; A E Pulver; C Laurent; K S Kendler; D Walsh; N Norton; N M Williams; S G Schwab; B Lerer; B J Mowry; A R Sanders; S E Antonarakis; J L Blouin; J F DeLeuze; J Mallet
Journal: Am J Hum Genet Date: 2000-08-02 Impact factor: 11.025

3. Identification of human PDE7B, a cAMP-specific phosphodiesterase.

Authors: T Sasaki; J Kotera; K Yuasa; K Omori
Journal: Biochem Biophys Res Commun Date: 2000-05-19 Impact factor: 3.575

4. Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample.

Authors: B Riley; D Thiselton; B S Maher; T Bigdeli; B Wormley; G O McMichael; A H Fanous; V Vladimirov; F A O'Neill; D Walsh; K S Kendler
Journal: Mol Psychiatry Date: 2009-10-20 Impact factor: 15.992

5. Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations.

Authors: Xiaoyan Jiang; Zaher Hanna; Mohammadi Kaouass; Luc Girard; Paul Jolicoeur
Journal: J Virol Date: 2002-09 Impact factor: 5.103

6. Dissecting the many genetic faces of schizophrenia.

Authors: Dan Rujescu; David A Collier
Journal: Epidemiol Psichiatr Soc Date: 2009 Apr-Jun

7. Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24.

Authors: B Lerer; R H Segman; A Hamdan; K Kanyas; O Karni; Y Kohn; M Korner; M Lanktree; M Kaadan; N Turetsky; A Yakir; B Kerem; F Macciardi
Journal: Mol Psychiatry Date: 2003-05 Impact factor: 15.992

8. Expanding the range of ZNF804A variants conferring risk of psychosis.

Authors: S Steinberg; O Mors; A D Børglum; O Gustafsson; T Werge; P B Mortensen; O A Andreassen; E Sigurdsson; T E Thorgeirsson; Y Böttcher; P Olason; R A Ophoff; S Cichon; I H Gudjonsdottir; O P H Pietiläinen; M Nyegaard; A Tuulio-Henriksson; A Ingason; T Hansen; L Athanasiu; J Suvisaari; J Lonnqvist; T Paunio; A Hartmann; G Jürgens; M Nordentoft; D Hougaard; B Norgaard-Pedersen; R Breuer; H-J Möller; I Giegling; B Glenthøj; H B Rasmussen; M Mattheisen; I Bitter; J M Réthelyi; T Sigmundsson; R Fossdal; U Thorsteinsdottir; M Ruggeri; S Tosato; E Strengman; L A Kiemeney; I Melle; S Djurovic; L Abramova; V Kaleda; M Walshe; E Bramon; E Vassos; T Li; G Fraser; N Walker; T Toulopoulou; J Yoon; N B Freimer; R M Cantor; R Murray; A Kong; V Golimbet; E G Jönsson; L Terenius; I Agartz; H Petursson; M M Nöthen; M Rietschel; L Peltonen; D Rujescu; D A Collier; H Stefansson; D St Clair; K Stefansson
Journal: Mol Psychiatry Date: 2010-01-05 Impact factor: 15.992

9. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

Authors: Shaun M Purcell; Naomi R Wray; Jennifer L Stone; Peter M Visscher; Michael C O'Donovan; Patrick F Sullivan; Pamela Sklar
Journal: Nature Date: 2009-07-01 Impact factor: 49.962

10. Common variants conferring risk of schizophrenia.

Authors: Hreinn Stefansson; Roel A Ophoff; Stacy Steinberg; Ole A Andreassen; Sven Cichon; Dan Rujescu; Thomas Werge; Olli P H Pietiläinen; Ole Mors; Preben B Mortensen; Engilbert Sigurdsson; Omar Gustafsson; Mette Nyegaard; Annamari Tuulio-Henriksson; Andres Ingason; Thomas Hansen; Jaana Suvisaari; Jouko Lonnqvist; Tiina Paunio; Anders D Børglum; Annette Hartmann; Anders Fink-Jensen; Merete Nordentoft; David Hougaard; Bent Norgaard-Pedersen; Yvonne Böttcher; Jes Olesen; René Breuer; Hans-Jürgen Möller; Ina Giegling; Henrik B Rasmussen; Sally Timm; Manuel Mattheisen; István Bitter; János M Réthelyi; Brynja B Magnusdottir; Thordur Sigmundsson; Pall Olason; Gisli Masson; Jeffrey R Gulcher; Magnus Haraldsson; Ragnheidur Fossdal; Thorgeir E Thorgeirsson; Unnur Thorsteinsdottir; Mirella Ruggeri; Sarah Tosato; Barbara Franke; Eric Strengman; Lambertus A Kiemeney; Ingrid Melle; Srdjan Djurovic; Lilia Abramova; Vasily Kaleda; Julio Sanjuan; Rosa de Frutos; Elvira Bramon; Evangelos Vassos; Gillian Fraser; Ulrich Ettinger; Marco Picchioni; Nicholas Walker; Timi Toulopoulou; Anna C Need; Dongliang Ge; Joeng Lim Yoon; Kevin V Shianna; Nelson B Freimer; Rita M Cantor; Robin Murray; Augustine Kong; Vera Golimbet; Angel Carracedo; Celso Arango; Javier Costas; Erik G Jönsson; Lars Terenius; Ingrid Agartz; Hannes Petursson; Markus M Nöthen; Marcella Rietschel; Paul M Matthews; Pierandrea Muglia; Leena Peltonen; David St Clair; David B Goldstein; Kari Stefansson; David A Collier
Journal: Nature Date: 2009-07-01 Impact factor: 49.962

25 in total

1. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.

Authors: Ling Weng; Yung-Feng Lin; Alina L Li; Chuan-En Wang; Sen Yan; Miao Sun; Marta A Gaertig; Naureen Mitha; Jun Kosaka; Taketoshi Wakabayashi; Xingshun Xu; Beisha Tang; Shihua Li; Xiao-Jiang Li
Journal: J Neurosci Date: 2013-05-08 Impact factor: 6.167

2. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC.

Authors: M L Hamshere; J T R Walters; R Smith; A L Richards; E Green; D Grozeva; I Jones; L Forty; L Jones; K Gordon-Smith; B Riley; F A O'Neill; T O'Neill; K S Kendler; P Sklar; S Purcell; J Kranz; D Morris; M Gill; P Holmans; N Craddock; A Corvin; M J Owen; M C O'Donovan
Journal: Mol Psychiatry Date: 2012-05-22 Impact factor: 15.992

3. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.

Authors: X Chen; G Lee; B S Maher; A H Fanous; J Chen; Z Zhao; A Guo; E van den Oord; P F Sullivan; J Shi; D F Levinson; P V Gejman; A Sanders; J Duan; M J Owen; N J Craddock; M C O'Donovan; J Blackman; D Lewis; G K Kirov; W Qin; S Schwab; D Wildenauer; K Chowdari; V Nimgaonkar; R E Straub; D R Weinberger; F A O'Neill; D Walsh; M Bronstein; A Darvasi; T Lencz; A K Malhotra; D Rujescu; I Giegling; T Werge; T Hansen; A Ingason; M M Nöethen; M Rietschel; S Cichon; S Djurovic; O A Andreassen; R M Cantor; R Ophoff; A Corvin; D W Morris; M Gill; C N Pato; M T Pato; A Macedo; H M D Gurling; A McQuillin; J Pimm; C Hultman; P Lichtenstein; P Sklar; S M Purcell; E Scolnick; D St Clair; D H R Blackwood; K S Kendler
Journal: Mol Psychiatry Date: 2010-09-14 Impact factor: 15.992

4. Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice.

Authors: Dongkai Guo; Shun Zhang; Hongyang Sun; Xingyun Xu; Zongbing Hao; Chenchen Mu; Xingshun Xu; Guanghui Wang; Haigang Ren
Journal: J Biol Chem Date: 2018-02-15 Impact factor: 5.157

5. Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration.

Authors: Jesús Muñoz-Estrada; Russell J Ferland
Journal: J Cell Sci Date: 2019-09-04 Impact factor: 5.285

6. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.

Authors: Xingshun Xu; Hao Yang; Yung-Feng Lin; Xiang Li; Austin Cape; Kerry J Ressler; Shihua Li; Xiao-Jiang Li
Journal: Proc Natl Acad Sci U S A Date: 2010-10-18 Impact factor: 11.205

10. Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample.

Authors: Anna Alkelai; Lior Greenbaum; Sara Lupoli; Yoav Kohn; Kyra Sarner-Kanyas; Edna Ben-Asher; Doron Lancet; Fabio Macciardi; Bernard Lerer
Journal: PLoS One Date: 2012-01-11 Impact factor: 3.240