| Literature DB >> 17470784 |
R K Lindemann1, A Newbold, K F Whitecross, L A Cluse, A J Frew, L Ellis, S Williams, A P Wiegmans, A E Dear, C L Scott, M Pellegrini, A Wei, V M Richon, Paul A Marks, S W Lowe, M J Smyth, R W Johnstone.
Abstract
Histone deacetylase inhibitors (HDACi) can elicit a range of biological responses that affect tumor growth and survival, including inhibition of cell cycle progression, induction of tumor cell-selective apoptosis, suppression of angiogenesis, and modulation of immune responses, and show promising activity against hematological malignancies in clinical trials. Using the Emu-myc model of B cell lymphoma, we screened tumors with defined genetic alterations in apoptotic pathways for therapeutic responsiveness to the HDACi vorinostat. We demonstrated a direct correlation between induction of tumor cell apoptosis in vivo and therapeutic efficacy. Vorinostat did not require p53 activity or a functional death receptor pathway to kill Emu-myc lymphomas and mediate a therapeutic response but depended on activation of the intrinsic apoptotic pathway with the proapoptotic BH3-only proteins Bid and Bim playing an important role. Our studies provide important information regarding the mechanisms of action of HDACi that have broad implications regarding stratification of patients receiving HDACi therapy alone or in combination with other anticancer agents.Entities:
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Year: 2007 PMID： 17470784 PMCID： PMC1876573 DOI： 10.1073/pnas.0702294104
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205