Literature DB >> 1747069

Chronic intoxication with acetaldehyde stimulates collagen biosynthesis in rat liver.

E Pawlicka1, E Bańkowski, K Sobolewski.   

Abstract

It was found that chronic intoxication of rats with acetaldehyde results in a distinct, progressive increase of 5(3)H-proline incorporation into collagen synthesized by liver. At the same time, biosynthesis of other proline-containing (noncollagenous) proteins does not change significantly. The effects are similar to those induced by chronic intoxication of rats with ethanol. Since acetaldehyde is an intermediary metabolite formed during ethanol oxidation in liver, it may be concluded that acetaldehyde is a factor responsible for alcohol-induced liver fibrosis.

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Year:  1991        PMID： 1747069     DOI： 10.1007/bf02098036

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  22 in total

1.  Hepatic collagen proline hydroxylase activity in alcoholic hepatitis: effect of d-penicillamine.

Authors:  E Mezey; J J Potter; F L Iber; W C Maddrey
Journal:  J Lab Clin Med       Date:  1979-01

2.  An increase of collagen biosynthesis precedes other symptoms of ethanol-induced liver damage in rats.

Authors:  E Pawlicka; E Bańkowski; L Chrostek; M Szmitkowski
Journal:  Drug Alcohol Depend       Date:  1988-10       Impact factor: 4.492

3.  Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.

Authors:  B Peterkofsky; R Diegelmann
Journal:  Biochemistry       Date:  1971-03-16       Impact factor: 3.162

Review 4.  Liver fibrosis.

Authors:  M Rojkind; R Pérez-Tamayo
Journal:  Int Rev Connect Tissue Res       Date:  1983

5.  Hepatic prolyl hydroxylase and collagen synthesis in patients with alcoholic liver disease.

Authors:  S W Mann; G C Fuller; J V Rodil; E I Vidins
Journal:  Gut       Date:  1979-10       Impact factor: 23.059

6.  Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes.

Authors:  H Moshage; A Casini; C S Lieber
Journal:  Hepatology       Date:  1990-09       Impact factor: 17.425

7.  An increase of collagen biosynthesis in livers of rats submitted to chronic intoxication with ethanol.

Authors:  E Bańkowski; E Pawlicka
Journal:  Mol Cell Biochem       Date:  1989-01-23       Impact factor: 3.396

8.  Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat.

Authors:  M A Leo; C S Lieber
Journal:  Hepatology       Date:  1983 Jan-Feb       Impact factor: 17.425

9.  Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.

Authors:  D A Brenner; M Chojkier
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

10.  Changes in hepatic collagen metabolism in rats produced by chronic ethanol feeding.

Authors:  E Mezey; J J Potter; R J Slusser; W Abdi
Journal:  Lab Invest       Date:  1977-02       Impact factor: 5.662
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