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Literature DB >> 17470646

Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model.

Matthew E Griffith¹, James E Moon, Erica N Johnson, Kyra P Clark, Joshua S Hawley, Duane R Hospenthal, Clinton K Murray.

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

Entities: Chemical Species

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Year: 2007 PMID： 17470646 PMCID： PMC1913230 DOI： 10.1128/AAC.00240-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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10. Pharmacokinetics of enrofloxacin HCl-2H₂O (Enro-C) in dogs and pharmacokinetic/pharmacodynamic Monte Carlo simulations against Leptospira spp.

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