| Literature DB >> 17470369 |
Kulbhushan Tikoo1, Deepak Kumar Bhatt, Anil Bhanudas Gaikwad, Vikram Sharma, Dhiraj G Kabra.
Abstract
Cisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced nephrotoxicity. Post-treatment of tannic acid prevents cisplatin (5mg/kg) induced nephrotoxicity and decreases poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4. In contrast, co-treatment of tannic acid potentiates the nephrotoxicity. Comparative nephrotoxicity studies show that co-treatment of tannic acid with reduced dose of cisplatin (1.5mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin.Entities:
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Year: 2007 PMID： 17470369 DOI： 10.1016/j.febslet.2007.04.036
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124