Literature DB >> 17467986

Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.

Takashi Yamamoto1, Koichi Fujita, Sayaka Asari, Akira Chiba, Yuka Kataba, Koji Ohsumi, Naoko Ohmuta, Yuko Iida, Chiori Ijichi, Satoshi Iwayama, Naoyuki Fukuchi, Masataka Shoji.   

Abstract

A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA(1)/CHO cells and rHSC cells were evaluated. Among them, 3-(4-[4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- y]]-benzylsulfanyl)-propionic acid (34) showed the most potent activities.

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Year:  2007        PMID： 17467986     DOI： 10.1016/j.bmcl.2007.04.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  3-(10-Chloro-9-anthr-yl)-5-[3-(prop-2-yn-yloxy)phenoxy-meth-yl]isoxazole.

Authors:  Juan Li; Hailing Xi; Jianming Zhang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-05-29

2.  Synthesis and Metabolism of BTN3A1 Ligands: Studies on Modifications of the Allylic Alcohol.

Authors:  Nicholas A Lentini; Chloe M Schroeder; Nyema M Harmon; Xueting Huang; Megan A Schladetsch; Benjamin J Foust; Michael M Poe; Chia-Hung Christine Hsiao; Andrew J Wiemer; David F Wiemer
Journal:  ACS Med Chem Lett       Date:  2020-12-04       Impact factor: 4.345

3.  Ethyl 5-(4-amino-phen-yl)isoxazole-3-carboxyl-ate.

Authors:  Jun-Tao Zhao; Jing-Jing Qi; You-Jun Zhou; Jia-Guo Lv; Ju Zhu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-17

4.  Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis.

Authors:  Akira Tokumura; Laura D Carbone; Yasuko Yoshioka; Junichi Morishige; Masaki Kikuchi; Arnold Postlethwaite; Mitchell A Watsky
Journal:  Int J Med Sci       Date:  2009-06-05       Impact factor: 3.738
  4 in total

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