Hsun-Chin Chao1, Yvan Vandenplas. 1. Division of Gastroenterology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University Medical College, Taoyuan, Taiwan. hero@adm.cgmh.org.tw
Abstract
OBJECTIVE: Infant constipation is a frequent condition in formula-fed infants. METHODS: A prospective randomized clinical trial was performed in infants who had constipation with Novalac-IT (IT group) versus a 20% strengthened formula (S group). Enrolled subjects had difficulties in defecating, hard stools, or low frequency of defecation (< or =3 times/wk). RESULTS:Ninety-three infants (47 boys, mean age 3.8 +/- 1.7 mo) were included because of hard consistency of (50.5%), low frequency in (44.1%), or painful (33.3%) defecation. A statistically significant improvement was observed after 4 and 8 wk of intervention in the IT group (P = 0.014 and P < 0.001, respectively). In the IT group, significantly more infants were symptom free at 4 wk (82.9% versus 50%, P = 0.029) and at 8 wk (89.1% versus 54.1%, P < 0.001). Increased stool weight was significant in the IT group after 4 and 8 wk (P = 0.048 and 0.029). CONCLUSION:Novalac-IT decreases constipation in formula-fed infants.
RCT Entities:
OBJECTIVE:Infantconstipation is a frequent condition in formula-fed infants. METHODS: A prospective randomized clinical trial was performed in infants who had constipation with Novalac-IT (IT group) versus a 20% strengthened formula (S group). Enrolled subjects had difficulties in defecating, hard stools, or low frequency of defecation (< or =3 times/wk). RESULTS: Ninety-three infants (47 boys, mean age 3.8 +/- 1.7 mo) were included because of hard consistency of (50.5%), low frequency in (44.1%), or painful (33.3%) defecation. A statistically significant improvement was observed after 4 and 8 wk of intervention in the IT group (P = 0.014 and P < 0.001, respectively). In the IT group, significantly more infants were symptom free at 4 wk (82.9% versus 50%, P = 0.029) and at 8 wk (89.1% versus 54.1%, P < 0.001). Increased stool weight was significant in the IT group after 4 and 8 wk (P = 0.048 and 0.029). CONCLUSION: Novalac-IT decreases constipation in formula-fed infants.
Authors: Dámaso D Infante; Oscar O Segarra; Susana S Redecillas; Marina M Alvarez; Mar M Miserachs Journal: Nutr J Date: 2011-05-19 Impact factor: 3.271
Authors: Robert A Arbuckle; Robyn T Carson; Linda Abetz-Webb; Jeffrey Hyams; Carlo Di Lorenzo; Barbara E Lewis; Elizabeth Gargon; Caroline Kurtz; Steven J Shiff; Jeffrey M Johnston Journal: Patient Date: 2014 Impact factor: 3.883