AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease. RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children.
AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS:Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease. RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children.
Authors: M Vogt; T Lang; G Frösner; C Klingler; A F Sendl; A Zeller; B Wiebecke; B Langer; H Meisner; J Hess Journal: N Engl J Med Date: 1999-09-16 Impact factor: 91.245
Authors: F Bortolotti; M Resti; R Giacchino; C Crivellaro; L Zancan; C Azzari; N Gussetti; L Tasso; S Faggion Journal: J Pediatr Date: 1998-09 Impact factor: 4.406
Authors: S N Lu; H C Chen; C M Tang; M H Wu; M L Yu; W L Chuang; C F Lu; W Y Chang; C J Chen Journal: Pediatr Infect Dis J Date: 1998-02 Impact factor: 2.129
Authors: Ahmed Medhat; Magda Shehata; Laurence S Magder; Nabiel Mikhail; Laila Abdel-Baki; Mohamed Nafeh; Mohamed Abdel-Hamid; G Thomas Strickland; Alan D Fix Journal: Am J Trop Med Hyg Date: 2002-05 Impact factor: 2.345
Authors: M S El-Raziky; M El-Hawary; N El-Koofy; S Okasha; M Kotb; K Salama; G Esmat; M El-Raziky; A M Abouzied; H El-Karaksy Journal: J Viral Hepat Date: 2004-09 Impact factor: 3.728
Authors: F Davidson; P Simmonds; J C Ferguson; L M Jarvis; B C Dow; E A Follett; C R Seed; T Krusius; C Lin; G A Medgyesi Journal: J Gen Virol Date: 1995-05 Impact factor: 3.891
Authors: Ahmed Megahed; Nanees Salem; Abeer Fathy; Tarik Barakat; Mona Abd El Latif Alsayed; Suzy Abd El Mabood; Khaled R Zalata; Ahmed F Abdalla Journal: World J Pediatr Date: 2017-01-27 Impact factor: 2.764
Authors: Suzan El Naghi; Tawhida Y Abdel-Ghaffar; Hanaa El-Karaksy; Elham F Abdel-Aty; Mona S El-Raziky; Aleef A Allam; Heba Helmy; Hanaa A El-Araby; Behairy E Behairy; Mohamed A El-Guindi; Hatem El-Sebaie; Aisha Y Abdel-Ghaffar; Nermin A Ehsan; Ahmed M El-Hennawy; Mostafa M Sira Journal: World J Gastroenterol Date: 2014-04-28 Impact factor: 5.742
Authors: Hanaa A El-Araby; Behairy E Behairy; Mohamed A El-Guindi; Nermin M Adawy; Alif A Allam; Ahmad M Sira; Mohamed A Khedr; Ibrahim A Elhenawy; Gihan A Sobhy; Hosam El Din M Basiouny; Menan E Salem; Samira A Abdel-Aziz; Ola A Fouad; Bassam A Ayoub Journal: Hepatol Int Date: 2019-09-12 Impact factor: 9.029