OBJECTIVE: To investigate the relationship between leptin and cytokines in depressed patients. METHODS: Thirty-three unmedicated patients (24 female, nine male) with depressive disorder and 23 healthy controls (16 female, seven male) were assessed for serum levels of interleukin (IL)-6, IL-1beta, tumour necrosis factor-alpha (TNF-alpha) and leptin. RESULTS: Levels of IL-6 and TNF-alpha in depressed patients were higher than in normal controls. There were significantly lower leptin levels in depressed patients than in normal controls. There were also significant differences in the leptin levels, being higher in female than in male patients, and in female than in male controls. CONCLUSIONS: IL-6 and TNF-alpha cytokines and leptin are important in the psychoimmunology of depressed patients. There were gender differences in leptin levels in depression.
OBJECTIVE: To investigate the relationship between leptin and cytokines in depressedpatients. METHODS: Thirty-three unmedicated patients (24 female, nine male) with depressive disorder and 23 healthy controls (16 female, seven male) were assessed for serum levels of interleukin (IL)-6, IL-1beta, tumour necrosis factor-alpha (TNF-alpha) and leptin. RESULTS: Levels of IL-6 and TNF-alpha in depressedpatients were higher than in normal controls. There were significantly lower leptin levels in depressedpatients than in normal controls. There were also significant differences in the leptin levels, being higher in female than in male patients, and in female than in male controls. CONCLUSIONS:IL-6 and TNF-alpha cytokines and leptin are important in the psychoimmunology of depressedpatients. There were gender differences in leptin levels in depression.
Authors: Tatiana Barichello; Graziele Milioli; Jaqueline S Generoso; Andreza L Cipriano; Caroline S Costa; Ana Paula Moreira; Márcia Carvalho Vilela; Clarissa M Comim; Antonio Lucio Teixeira; João Quevedo Journal: J Neural Transm (Vienna) Date: 2011-12-13 Impact factor: 3.575
Authors: Wiebke Greggersen; Sebastian Rudolf; Eva Fassbinder; Leif Dibbelt; Beate M Stoeckelhuber; Fritz Hohagen; Kerstin M Oltmanns; Kai G Kahl; Ulrich Schweiger Journal: Eur Arch Psychiatry Clin Neurosci Date: 2011-02-26 Impact factor: 5.270
Authors: Elizabeth A Lawson; Karen K Miller; Justine I Blum; Erinne Meenaghan; Madhusmita Misra; Kamryn T Eddy; David B Herzog; Anne Klibanski Journal: Clin Endocrinol (Oxf) Date: 2012-04 Impact factor: 3.478
Authors: Benjamin P Chapman; Ayesha Khan; Mary Harper; Doug Stockman; Kevin Fiscella; James Walton; Paul Duberstein; Nancy Talbot; Jeffrey M Lyness; Jan Moynihan Journal: Brain Behav Immun Date: 2008-12-31 Impact factor: 7.217
Authors: Magdalena Olszanecka-Glinianowicz; Barbara Zahorska-Markiewicz; Piotr Kocełak; Joanna Janowska; Elzbieta Semik-Grabarczyk; Tomasz Wikarek; Wojciech Gruszka; Piotr Dabrowski Journal: Mediators Inflamm Date: 2009-06-29 Impact factor: 4.711