OBJECTIVE: Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. METHODS: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. RESULTS: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. CONCLUSIONS: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.
OBJECTIVE:Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. METHODS: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. RESULTS: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. CONCLUSIONS: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.
Authors: Robert P Kauffman; V Daniel Castracane; Debie L White; Sandra D Baldock; Ron Owens Journal: Gynecol Endocrinol Date: 2005-09 Impact factor: 2.260
Authors: Anastasia I Petra; Smaro Panagiotidou; Erifili Hatziagelaki; Julia M Stewart; Pio Conti; Theoharis C Theoharides Journal: Clin Ther Date: 2015-05-01 Impact factor: 3.393
Authors: Ajaykumar N Sharma; Bruno Fernando Borges da Costa e Silva; Jair C Soares; André F Carvalho; Joao Quevedo Journal: J Affect Disord Date: 2016-03-02 Impact factor: 4.839
Authors: Matheus A Pasquali; Bernard L Harlow; Claudio N Soares; Michael W Otto; Lee S Cohen; Luciano Minuzzi; Daniel P Gelain; Jose Claudio F Moreira; Benicio N Frey Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-05-26 Impact factor: 5.270
Authors: T Xie; M G Stathopoulou; F de Andrés; G Siest; H Murray; M Martin; J Cobaleda; A Delgado; J Lamont; E Peñas-LIedó; A LLerena; S Visvikis-Siest Journal: Transl Psychiatry Date: 2017-03-07 Impact factor: 6.222