BACKGROUND: Modern-generation metal-on-metal articulations have a high wear resistance and may therefore be able to improve the long-term performance of artificial joints. However, the biological effects are still under debate. This study was undertaken to review the histopathological changes in neo-capsule tissues of different metal-on-metal hip arthroplasties. METHODS: Neo-capsule tissue samples from 46 hips with modern second-generation metal-on-metal articulations (39 hip resurfacings and 7 non-cemented total hip replacements) with a variety of failure mechanisms were examined histopathologically and immunohistochemically. RESULTS: A distinct lymphocytic infiltration was found in all cases with in situ times of more than 7 months, consisting of CD20-positive B-lymphocytes and CD3-positive T-lymphocytes and sometimes thinly distributed CD138-positive plasma cells without dominant T-cell or plasma cell infiltrates. INTERPRETATION: This distinct lymphocytic infiltration has not been reported in tissue analyses of metal- or ceramic-on-polyethylene hip replacements, and may therefore be considered to be a characteristic histological pattern of tissue reactions on metal particles and/or ions around metal-on-metal bearings.
BACKGROUND: Modern-generation metal-on-metal articulations have a high wear resistance and may therefore be able to improve the long-term performance of artificial joints. However, the biological effects are still under debate. This study was undertaken to review the histopathological changes in neo-capsule tissues of different metal-on-metalhip arthroplasties. METHODS: Neo-capsule tissue samples from 46 hips with modern second-generation metal-on-metal articulations (39 hip resurfacings and 7 non-cemented total hip replacements) with a variety of failure mechanisms were examined histopathologically and immunohistochemically. RESULTS: A distinct lymphocytic infiltration was found in all cases with in situ times of more than 7 months, consisting of CD20-positive B-lymphocytes and CD3-positive T-lymphocytes and sometimes thinly distributed CD138-positive plasma cells without dominant T-cell or plasma cell infiltrates. INTERPRETATION: This distinct lymphocytic infiltration has not been reported in tissue analyses of metal- or ceramic-on-polyethylene hip replacements, and may therefore be considered to be a characteristic histological pattern of tissue reactions on metal particles and/or ions around metal-on-metal bearings.
Authors: Vincent Y Ng; Adolph V Lombardi; Keith R Berend; Michael D Skeels; Joanne B Adams Journal: Clin Orthop Relat Res Date: 2011-02 Impact factor: 4.176
Authors: Frank S Fröschen; Nadine Gravius; Jan-Frederic Lau; Thomas Martin Randau; Eva Kaup; Max J Friedrich; Sascha Gravius Journal: Int Orthop Date: 2018-12-11 Impact factor: 3.075
Authors: V Krenn; L Morawietz; M Jakobs; H Kienapfel; R Ascherl; L Bause; H Kuhn; G Matziolis; M Skutek; T Gehrke Journal: Pathologe Date: 2011-05 Impact factor: 1.011
Authors: V Krenn; L Morawietz; H Kienapfel; R Ascherl; G Matziolis; J Hassenpflug; M Thomsen; P Thomas; M Huber; C Schuh; D Kendoff; D Baumhoer; M G Krukemeyer; G Perino; J Zustin; I Berger; W Rüther; C Poremba; T Gehrke Journal: Z Rheumatol Date: 2013-05 Impact factor: 1.372