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Literature DB >> 17464449

Hepatocyte growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells.

Sheng-hua Chu¹, Yan-bin Ma, Hong Zhang, Dong-fu Feng, Zhi-an Zhu, Zhi-qiang Li, Xian-hou Yuan.

Abstract

Hepatocyte growth factor (HGF) is a pleiotrophic cytokine that stimulates motility and invasion of several cancer cell types and induces angiogenesis, which is known to be expressed in several malignancies including glioma. The effect of transforming growth factor-beta (TGF-beta) isoforrns as well as gangliosides on HGF production was investigated in human glioma cell lines. TGF-beta isoforms and gangliosides were found to differentially stimulate HGF production by these cells. The ganglioside GD3 enhanced this release to the greatest extent and the stimulation was more marked in a glioblastoma cell line than in the two other anaplastic astrocytoma cell lines. These results suggest that both TGF-betas and gangliosides may act as indirect angiogenic factors by stimulating HGF secretion.

Entities: Chemical Disease Gene Species

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Year: 2007 PMID： 17464449 DOI： 10.1007/s11060-007-9387-2

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

46 in total

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8 in total

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