Literature DB >> 8603372

Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro.

S Koochekpour1, A Merzak, G J Pilkington.   

Abstract

Vascular endothelial growth factor (VEGF) is an angiogenic factor which is known to be expressed in several malignancies including glioma. The effect of transforming growth factor-beta (TGF-beta) isoforms as well as gangliosides on VEGF production was investigated in human glioma cell lines. TGF-beta isoforms and gangliosides were found to differentially stimulate VEGF production by these cells. The ganglioside GD3 enhanced this release to the greatest extent and the stimulation was more marked in a glioblastoma cell line than in the two other anaplastic astrocytoma cell lines. These results suggest that both TGF-betas and gangliosides may act as indirect angiogenic factors by stimulating VEGF secretion.

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Year:  1996        PMID： 8603372     DOI： 10.1016/0304-3835(96)04161-4

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  28 in total

1.  Assessment of the molecular expression and structure of gangliosides in brain metastasis of lung adenocarcinoma by an advanced approach based on fully automated chip-nanoelectrospray mass spectrometry.

Authors:  Alina D Zamfir; Alina Serb; Željka Vukeli; Corina Flangea; Catalin Schiopu; Dragana Fabris; Svjetlana Kalanj-Bognar; Florina Capitan; Eugen Sisu
Journal:  J Am Soc Mass Spectrom       Date:  2011-10-15       Impact factor: 3.109

Review 2.  Diverse roles of the vasculature within the neural stem cell niche.

Authors:  Joshua S Goldberg; Karen K Hirschi
Journal:  Regen Med       Date:  2009-11       Impact factor: 3.806

3.  Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.

Authors:  Mengxian Zhang; Tobias W Herion; Carmen Timke; Na Han; Kai Hauser; Klaus J Weber; Peter Peschke; Ute Wirkner; Michael Lahn; Peter E Huber
Journal:  Neoplasia       Date:  2011-06       Impact factor: 5.715

Review 4.  Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs.

Authors:  I F Dunn; O Heese; P M Black
Journal:  J Neurooncol       Date:  2000 Oct-Nov       Impact factor: 4.130

Review 5.  Inhibition of vascular endothelial growth factor in the treatment of solid tumors.

Authors:  Kim Margolin
Journal:  Curr Oncol Rep       Date:  2002-01       Impact factor: 5.075

6.  Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a.

Authors:  Purna Mukherjee; Anthony C Faber; Laura M Shelton; Rena C Baek; Thomas C Chiles; Thomas N Seyfried
Journal:  J Lipid Res       Date:  2008-02-20       Impact factor: 5.922

7.  Promotion of stem cell proliferation by vegetable peptone.

Authors:  J Lee; J Lee; H Hwang; E Jung; S Huh; J Hyun; D Park
Journal:  Cell Prolif       Date:  2009-07-14       Impact factor: 6.831

8.  Intrathecal inflammation precedes development of Alzheimer's disease.

Authors:  E Tarkowski; N Andreasen; A Tarkowski; K Blennow
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-09       Impact factor: 10.154

Review 9.  Antibody-based immunotherapy for malignant glioma.

Authors:  Patrick C Gedeon; Katherine A Riccione; Peter E Fecci; John H Sampson
Journal:  Semin Oncol       Date:  2014-06-12       Impact factor: 4.929

10.  Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: biochemical characterization and biological consequences in endothelial cell cultures.

Authors:  M Rusnati; E Tanghetti; C Urbinati; G Tulipano; S Marchesini; M Ziche; M Presta
Journal:  Mol Biol Cell       Date:  1999-02       Impact factor: 4.138
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