Literature DB >> 12023111

High-speed combinatorial synthesis utilizing microwave irradiation.

C Oliver Kappe1.   

Abstract

Recent advances in microwave-assisted combinatorial chemistry include high-speed solid-phase and polymer-supported organic synthesis, rapid parallel synthesis of compound libraries, and library generation by automated sequential microwave irradiation. In addition, new instrumentation for high-throughput microwave-assisted synthesis continues to be developed at a steady pace. The impressive speed combined with the unmatched control over reaction parameters justifies the growing interest in this application of microwave heating.

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Year:  2002        PMID: 12023111     DOI: 10.1016/s1367-5931(02)00306-x

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN: 1367-5931            Impact factor:   8.822


  22 in total

1.  Enhancing stereochemical diversity by means of microwave irradiation in the absence of solvent: synthesis of highly substituted nitroproline esters via 1,3-dipolar reactions.

Authors:  Angel Díaz-Ortiz; Antonio de la Hoz; M Antonia Herrero; Pilar Prieto; Ana Sánchez-Migallón; Fernando P Cossío; Ana Arrieta; Silvia Vivanco; Concepción Foces-Foces
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

2.  Microwave-assisted Mannich-type three-component reactions.

Authors:  Nicholas E Leadbeater; Hanna M Torenius; Heather Tye
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

3.  Combining the use of solid-supported transition metal catalysis with microwave irradiation in solution-phase parallel library synthesis.

Authors:  Michael G Organ; Stanislas Mayer; Franck Lepifre; Blaise N'Zemba; Jayantilal Khatri
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

4.  A rapid microwave protocol for Heck vinylation of aryl chlorides under air.

Authors:  Gopal K Datta; Karl S A Vallin; Mats Larhed
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

5.  N-vinylpyridinium and -ammonium tetrafluoroborate salts: new electrophilic coupling partners for Pd(0)-catalyzed Suzuki cross-coupling reactions.

Authors:  Keith R Buszek; Neil Brown
Journal:  Org Lett       Date:  2007-01-25       Impact factor: 6.005

Review 6.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

7.  Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions.

Authors:  Yimin Lu; Wei Zhang
Journal:  QSAR Comb Sci       Date:  2004

8.  N-Vinylpyridinium tetrafluoroborate salts as reagents for the stereoselective and regioselective synthesis of symmetrical (2E,4E)-1,6-dioxo-2,4-dienes.

Authors:  Ge Gao; Neil Brown; Machiko Minatoya; Keith R Buszek
Journal:  Tetrahedron Lett       Date:  2008-11-10       Impact factor: 2.415

9.  Microwave-Enhanced High-Speed Fluorous Synthesis.

Authors:  Wei Zhang
Journal:  Top Curr Chem       Date:  2006-08-30

10.  Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.

Authors:  Paolo Grieco; Minying Cai; Lu Liu; Alexander Mayorov; Kevin Chandler; Dev Trivedi; Guangxin Lin; Pietro Campiglia; Ettore Novellino; Victor J Hruby
Journal:  J Med Chem       Date:  2008-04-15       Impact factor: 7.446

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