Literature DB >> 17462892

Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A.

Nicholas Aberle1, Jenny Catimel, Edouard C Nice, Keith G Watson.   

Abstract

A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.

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Year:  2007        PMID： 17462892     DOI： 10.1016/j.bmcl.2007.04.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Total synthesis and cytotoxicity of Leucetta alkaloids.

Authors:  Panduka B Koswatta; Sabha Kasiri; Jayanta K Das; Arunoday Bhan; Heather M Lima; Beatriz Garcia-Barboza; Nicole N Khatibi; Muhammed Yousufuddin; Subhrangsu S Mandal; Carl J Lovely
Journal:  Bioorg Med Chem       Date:  2017-01-20       Impact factor: 3.641

2.  A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support.

Authors:  Yangmei Li; Marc Giulianotti; Richard A Houghten
Journal:  Tetrahedron Lett       Date:  2010-10-27       Impact factor: 2.415

3.  Total syntheses and cytotoxicity of kealiiquinone, 2-deoxy-2-aminokealiiquinone and analogs.

Authors:  Jayanta Das; Arunoday Bhan; Subhrangsu S Mandal; Carl J Lovely
Journal:  Bioorg Med Chem Lett       Date:  2013-09-06       Impact factor: 2.823

4.  Total Syntheses of Naamidine G and 14-Methoxynaamidine G.

Authors:  Panduka B Koswatta; Carl J Lovely
Journal:  Tetrahedron Lett       Date:  2010-01-06       Impact factor: 2.415

5.  Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues.

Authors:  Joseph B Gibbons; Justin M Salvant; Rachel M Vaden; Ki-Hyeok Kwon; Bryan E Welm; Ryan E Looper
Journal:  J Org Chem       Date:  2015-09-24       Impact factor: 4.354

6.  Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.

Authors:  Christoph Grohmann; Francesca Walker; Mark Devlin; Meng-Xiao Luo; Anderly C Chüeh; Judy Doherty; François Vaillant; Gwo-Yaw Ho; Matthew J Wakefield; Clare E Weeden; Alvin Kamili; Jayne Murray; Sela T Po'uha; Janet Weinstock; Serena R Kane; Maree C Faux; Esmee Broekhuizen; Ye Zheng; Kristy Shield-Artin; Nadia J Kershaw; Chin Wee Tan; Helen M Witchard; Gregor Ebert; Susan A Charman; Ian Street; Maria Kavallaris; Michelle Haber; Jamie I Fletcher; Marie-Liesse Asselin-Labat; Clare L Scott; Jane E Visvader; Geoffrey J Lindeman; Keith G Watson; Antony W Burgess; Guillaume Lessene
Journal:  Cell Death Dis       Date:  2021-03-12       Impact factor: 8.469
  6 in total

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