Literature DB >> 17460581

Role of genetic factors and inflammation in age-related macular degeneration.

Darius M Moshfeghi1, Mark S Blumenkranz.   

Abstract

Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 10q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed.

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Year:  2007        PMID： 17460581     DOI： 10.1097/IAE.0b013e31802e3e9b

Source DB:  PubMed          Journal:  Retina        ISSN： 0275-004X            Impact factor:   4.256


  20 in total

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Review 4.  Genetic architecture of colorectal cancer.

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5.  Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease.

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Authors:  M Michaelides; L L Chen; M A Brantley; J L Andorf; E M Isaak; S A Jenkins; G E Holder; A C Bird; E M Stone; A R Webster
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9.  Combination therapy for choroidal neovascularisation.

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10.  Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Atherosclerosis.

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