OBJECTIVES: To study the different responses by sex to zinc supplementation among young children. STUDY CHILDREN AND METHODS: Double-blind randomized controlled trial of zinc supplementation in 686 children aged 6-30 months, conducted in Nouna, a rural area of Burkina Faso. Children received either a 12.5-mg zinc sulfate tablet or a placebo every day for about 6 months. Outcomes were morbidity, nutritional status, and mortality. RESULTS: Results revealed significant differences between boys and girls in their responses to zinc supplementation. Boys who received the zinc preparation had fewer days with diarrhea than did control boys (RR = 0.88, P = 0.05), especially less nonfebrile diarrhea (RR = 0.72, P < 0.001) and less dysentery (RR = 0.65, P = 0.05), but more ear infections (RR = 4.00, P < 0.001). By contrast, girls who received the zinc supplement had the same prevalence of diarrhea as did control girls, but more dysentery (RR = 3.70, P < 0.001), fewer ear infections (RR = 0.39, P < 0.001), and fewer eye infections (RR = 0.41, P < 0.001). The effect of supplementation on nutritional status was not detectable in boys, but girls who received supplementation experienced a faster growth velocity in height than did control girls (P = 0.004) and a faster growth velocity for weight and height if they were wasted and not stunted at baseline (P = 0.003). CONCLUSIONS:Zinc supplementation had positive, nil, or negative effects depending on pathological condition, and the effects were different for boys than for girls.
RCT Entities:
OBJECTIVES: To study the different responses by sex to zinc supplementation among young children. STUDY CHILDREN AND METHODS: Double-blind randomized controlled trial of zinc supplementation in 686 children aged 6-30 months, conducted in Nouna, a rural area of Burkina Faso. Children received either a 12.5-mg zinc sulfate tablet or a placebo every day for about 6 months. Outcomes were morbidity, nutritional status, and mortality. RESULTS: Results revealed significant differences between boys and girls in their responses to zinc supplementation. Boys who received the zinc preparation had fewer days with diarrhea than did control boys (RR = 0.88, P = 0.05), especially less nonfebrile diarrhea (RR = 0.72, P < 0.001) and less dysentery (RR = 0.65, P = 0.05), but more ear infections (RR = 4.00, P < 0.001). By contrast, girls who received the zinc supplement had the same prevalence of diarrhea as did control girls, but more dysentery (RR = 3.70, P < 0.001), fewer ear infections (RR = 0.39, P < 0.001), and fewer eye infections (RR = 0.41, P < 0.001). The effect of supplementation on nutritional status was not detectable in boys, but girls who received supplementation experienced a faster growth velocity in height than did control girls (P = 0.004) and a faster growth velocity for weight and height if they were wasted and not stunted at baseline (P = 0.003). CONCLUSIONS: Zinc supplementation had positive, nil, or negative effects depending on pathological condition, and the effects were different for boys than for girls.
Authors: Yosra S Abd El-Ghaffar; Ahmed Esmat Shouman; Sally Adel Hakim; Yasmin Gamal Abdo El Gendy; Maha Magdy Mahmoud Wahdan Journal: Glob Pediatr Health Date: 2022-06-17
Authors: Graeme P Young; Elissa K Mortimer; Geetha L Gopalsamy; David H Alpers; Henry J Binder; Mark J Manary; Balakrishnan S Ramakrishna; Ian L Brown; Thomas G Brewer Journal: Am J Clin Nutr Date: 2014-08-13 Impact factor: 7.045
Authors: Camila A A de Queiroz; Said Gonçalves C Fonseca; Priscila B Frota; Italo L Figueiredo; Karoline S Aragão; Carlos Emanuel C Magalhães; Cibele B M de Carvalho; Aldo Ângelo M Lima; Ronaldo A Ribeiro; Richard L Guerrant; Sean R Moore; Reinaldo B Oriá Journal: BMC Gastroenterol Date: 2014-08-05 Impact factor: 3.067
Authors: Ali Sié; Mamadou Ouattara; Mamadou Bountogo; Clarisse Dah; Guillaume Compaore; Elodie Lebas; Jessica M Brogdon; Ying Lin; William W Godwin; Kieran S O'Brien; Benjamin F Arnold; Thomas M Lietman; Catherine E Oldenburg Journal: Am J Trop Med Hyg Date: 2021-10-25 Impact factor: 3.707