Literature DB >> 17454938

Methotrexate-related lymphomatoid granulomatosis: a case report of spontaneous regression of large tumours in multiple organs after cessation of methotrexate therapy in rheumatoid arthritis.

K Shimada1, T Matsui, M Kawakami, H Nakayama, Y Ozawa, H Mitomi, S Tohma.   

Abstract

We describe a 54-year-old female patient with rheumatoid arthritis (RA) and Sjögren's syndrome (SS) who presented with right chest pain and a large mass visible in the upper right field of a chest X-ray. Computed tomography (CT) showed multiple tumours in both lungs, the liver, and the spleen. The right lung tumour was 8 cm in diameter with a cavity. Biopsy of the lung and liver revealed lymphomatoid granulomatosis (LG) and diffuse large B-cell lymphoma (DLBCL). These lesions spontaneously regressed after withdrawal of methotrexate without any therapy for the lymphoma. This is the first report of self-limiting LG in a patient, complicated with methotrexate-treated RA.

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Year:  2007        PMID： 17454938     DOI： 10.1080/03009740600902403

Source DB:  PubMed          Journal:  Scand J Rheumatol        ISSN： 0300-9742            Impact factor:   3.641


  9 in total

Review 1.  Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.

Authors:  Christopher Melani; Elaine S Jaffe; Wyndham H Wilson
Journal:  Blood       Date:  2020-04-16       Impact factor: 22.113

2.  A surgical case of methotrexate-associated lymphomatoid granuloma.

Authors:  Hajime Watanabe; Ryota Masuda; Tomohiko Matsuzaki; Rurika Hamanaka; Yoichiro Ikoma; Takayuki Nakano; Kana Oiwa; Mitsutomo Kohno; Masayuki Iwazaki
Journal:  Gen Thorac Cardiovasc Surg       Date:  2017-12-19

3.  Imaging manifestations of autoimmune disease-associated lymphoproliferative disorders of the lung.

Authors:  Geewon Lee; Ho Yun Lee; Kyung Soo Lee; Kyung Jong Lee; Hoon-Suk Cha; Joungho Han; Man Pyo Chung
Journal:  Clin Rheumatol       Date:  2013-06-02       Impact factor: 2.980

Review 4.  Histopathological Features of Methotrexate Induced Pulmonary Lesions in Rheumatoid Arthritis Patients: A Systematic Review of Case Reports.

Authors:  Anthony Thaniyan; Foad F A Ayman; Hyder O Mirghani; Badr A Al-Sayed; Tarig H Merghani
Journal:  Open Access Maced J Med Sci       Date:  2017-04-08

Review 5.  The Spontaneous Regression of Grade 3 Methotrexate-related Lymphomatoid Granulomatosis: A Case Report and Literature Review.

Authors:  Naoto Aiko; Akimasa Sekine; Shigeaki Umeda; Takuma Katano; Goshi Matama; Kohsuke Isomoto; Ryota Otoshi; Takashi Ogura
Journal:  Intern Med       Date:  2018-06-06       Impact factor: 1.271

Review 6.  Endobronchial Manifestation of Methotrexate-induced Lymphoproliferative Disorder.

Authors:  Tatsuyoshi Ikeue; Hiroaki Kawachi; Hiroshi Yoshida; Eiichiro Tanaka; Susumu Noguchi; Akari Fukao; Satoshi Terashita; Tomoko Tajiri; Sadao Horikawa; Takakazu Sugita
Journal:  Intern Med       Date:  2019-02-01       Impact factor: 1.271

Review 7.  Methotrexate-Associated Pneumonitis and Rheumatoid Arthritis-Interstitial Lung Disease: Current Concepts for the Diagnosis and Treatment.

Authors:  George E Fragoulis; Elena Nikiphorou; Jörg Larsen; Peter Korsten; Richard Conway
Journal:  Front Med (Lausanne)       Date:  2019-10-23

Review 8.  [Treatment of rheumatic diseases and pulmonary toxicity].

Authors:  J Schreiber; U Müller-Ladner
Journal:  Pneumologe (Berl)       Date:  2018-09-25

9.  Effects of a biologic agent in a patient with rheumatoid arthritis after treatment for methotrexate-associated B-cell lymphoma: a case report.

Authors:  Takeshi Kuroda; Hiroe Sato; Takeshi Nakatsue; Yoko Wada; Shuichi Murakami; Masaaki Nakano; Ichiei Narita
Journal:  BMC Res Notes       Date:  2014-04-11
  9 in total

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