Literature DB >> 17454419

So-called "clinical equipoise" and the argument from design.

Fred Gifford1.   

Abstract

In this article, I review and expand upon arguments showing that Freedman's so-called "clinical equipoise" criterion cannot serve as an appropriate guide and justification for the moral legitimacy of carrying out randomized clinical trials. At the same time, I try to explain why this approach has been given so much credence despite compelling arguments against it, including the fact that Freedman's original discussion framed the issues in a misleading way, making certain things invisible: Clinical equipoise is conflated with community equipoise, and several versions of each are also conflated. But a misleading impression is given that, rather than distinct criteria being arbitrarily conflated, a puzzle is solved and a number of features unified. Various issues are pushed under the rug, hiding flaws of the "clinical equipoise" approach and thus deceiving us into thinking that we have a solution when we do not. Particularly significant is the ignoring of the crucial distinction between the individual patient decision and the policy decision.

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Year:  2007        PMID: 17454419     DOI: 10.1080/03605310701255743

Source DB:  PubMed          Journal:  J Med Philos        ISSN: 0360-5310


  7 in total

Review 1.  Equipoise: asking the right questions for clinical trial design.

Authors:  Steven Joffe; Franklin G Miller
Journal:  Nat Rev Clin Oncol       Date:  2012-01-10       Impact factor: 66.675

Review 2.  Clinical trials in orthopaedics research. Part II. Prioritization for randomized controlled clinical trials.

Authors:  Jeffrey N Katz; James G Wright; Elena Losina
Journal:  J Bone Joint Surg Am       Date:  2011-04-06       Impact factor: 5.284

3.  Confusions in the equipoise concept and the alternative of fully informed overlapping rational decisions.

Authors:  David W Chambers
Journal:  Med Health Care Philos       Date:  2011-05

4.  Why the NIH Trial to Assess Chelation Therapy (TACT) should be abandoned.

Authors:  Kimball C Atwood; Elizabeth Woeckner; Robert S Baratz; Wallace I Sampson
Journal:  Medscape J Med       Date:  2008-05-13

5.  Challenges of clinical trial design when there is lack of clinical equipoise: use of a response-conditional crossover design.

Authors:  Chunqin Deng; Kim Hanna; Vera Bril; Marinos C Dalakas; Peter Donofrio; Pieter A van Doorn; Hans-Peter Hartung; Ingemar S J Merkies
Journal:  J Neurol       Date:  2011-08-07       Impact factor: 4.849

6.  Ethical complexities of screening for depression and intimate partner violence (IPV) in intervention studies.

Authors:  Victoria J Palmer; Jane S Yelland; Angela J Taft
Journal:  BMC Public Health       Date:  2011-11-25       Impact factor: 3.295

7.  A call for structured ethics appendices in social science papers.

Authors:  Edward Asiedu; Dean Karlan; Monica Lambon-Quayefio; Christopher Udry
Journal:  Proc Natl Acad Sci U S A       Date:  2021-07-20       Impact factor: 11.205

  7 in total

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