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Literature DB >> 17449826

Common aging pathways in worms, flies, mice and humans.

Abstract

Development of functional genomics tools has made it possible to define the aging process by performing genome-wide scans for transcriptional differences between the young and the old. Global screens for age regulation have been performed for worms and flies, as well as many tissues in mice and humans. Recent work has begun to analyze the similarities and differences in transcriptional changes in aging among different species. Most age-related expression changes are specific for a given species, but genes in one pathway (the electron transport chain pathway) show common age regulation in species from worms to humans. Evolutionary theories of aging provide a basis to understand how age regulation of a genetic pathway might be preserved between distantly related species.

Entities: Species

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Year: 2007 PMID： 17449826 DOI： 10.1242/jeb.004887

Source DB: PubMed Journal: J Exp Biol ISSN： 0022-0949 Impact factor: 3.312

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Cited

40 in total

1. Midlife gene expressions identify modulators of aging through dietary interventions.

Authors: Bing Zhou; Liu Yang; Shoufeng Li; Jialiang Huang; Haiyang Chen; Lei Hou; Jinbo Wang; Christopher D Green; Zhen Yan; Xun Huang; Matt Kaeberlein; Li Zhu; Huasheng Xiao; Yong Liu; Jing-Dong J Han
Journal: Proc Natl Acad Sci U S A Date: 2012-04-16 Impact factor: 11.205

2. In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life.

Authors: G E Jules; S Pratap; A Ramesh; D B Hood
Journal: Toxicology Date: 2012-02-21 Impact factor: 4.221

3. Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.

Authors: Eleni N Tsakiri; Gerasimos P Sykiotis; Issidora S Papassideri; Vassilis G Gorgoulis; Dirk Bohmann; Ioannis P Trougakos
Journal: FASEB J Date: 2013-03-01 Impact factor: 5.191

Review 4. Rhesus macaques as a tractable physiological model of human ageing.

Authors: Kenneth L Chiou; Michael J Montague; Elisabeth A Goldman; Marina M Watowich; Sierra N Sams; Jeff Song; Julie E Horvath; Kirstin N Sterner; Angelina V Ruiz-Lambides; Melween I Martínez; James P Higham; Lauren J N Brent; Michael L Platt; Noah Snyder-Mackler
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2020-09-21 Impact factor: 6.237

10. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors: Douglas B Kell
Journal: BMC Med Genomics Date: 2009-01-08 Impact factor: 3.063

Common aging pathways in worms, flies, mice and humans.

1. Midlife gene expressions identify modulators of aging through dietary interventions.

2. In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life.

3. Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.

Review 4. Rhesus macaques as a tractable physiological model of human ageing.

5. Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging.

6. Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging.

7. Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.

8. The effects of aging on the molecular and cellular composition of the prostate microenvironment.

Review 9. Effects of calorie restriction on life span of microorganisms.

10. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.