BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a distinct clinical form of oral leukoplakia defined by its progressive clinical course, changing clinical and histopathological features, and potential to develop into cancer. PVL behaves in a more aggressive and relentless manner than the more innocuous white oral lesions that it can resemble clinically. METHODS: A PubMed search was conducted which identified studies that examined patients with PVL and reported data meeting inclusion criteria. RESULTS: PVL is seen much more frequently in females and most often diagnosed after the sixth decade of life. Tobacco use is not strongly linked to the presence of PVL (63% of patients did not use tobacco products). Most (74%) of the patients with PVL progressed to oral carcinoma. CONCLUSION: PVL is a persistent and progressive oral lesion that requires very close follow-up along with early and aggressive treatment to increase the chances of a favorable outcome.
BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a distinct clinical form of oral leukoplakia defined by its progressive clinical course, changing clinical and histopathological features, and potential to develop into cancer. PVL behaves in a more aggressive and relentless manner than the more innocuous white oral lesions that it can resemble clinically. METHODS: A PubMed search was conducted which identified studies that examined patients with PVL and reported data meeting inclusion criteria. RESULTS: PVL is seen much more frequently in females and most often diagnosed after the sixth decade of life. Tobacco use is not strongly linked to the presence of PVL (63% of patients did not use tobacco products). Most (74%) of the patients with PVL progressed to oral carcinoma. CONCLUSION: PVL is a persistent and progressive oral lesion that requires very close follow-up along with early and aggressive treatment to increase the chances of a favorable outcome.
Authors: Leticia Bagan; Guillermo T Sáez; M Carmen Tormos; Carlos Labaig-Rueda; Judith Murillo-Cortes; Jose V Bagan Journal: Clin Oral Investig Date: 2015-08-09 Impact factor: 3.573
Authors: Lester D R Thompson; Sarah G Fitzpatrick; Susan Müller; Ellen Eisenberg; Jasbir D Upadhyaya; Mark W Lingen; Nadarajah Vigneswaran; Sook-Bin Woo; Indraneel Bhattacharyya; Elizabeth A Bilodeau; Roman Carlos; Mohammed N Islam; Marino E Leon; James S Lewis; Kelly R Magliocca; Haresh Mani; Mitra Mehrad; Bibianna Purgina; Mary Richardson; Bruce M Wenig; Donald M Cohen Journal: Head Neck Pathol Date: 2021-01-07