Literature DB >> 17447782

Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist.

Guo Li1, Karen Watson, Robert W Buckheit, Yan Zhang.   

Abstract

The total synthesis of anibamine, the first and only natural product known as a chemokine receptor CCR5 antagonist, is reported herein. Anibamine was synthesized from acetylacetone and cyanoacetamide in 10 steps.

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Year:  2007        PMID： 17447782     DOI： 10.1021/ol070748n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

Review 1.  Targeting CCR5 for anti-HIV research.

Authors:  W-G Gu; X-Q Chen
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2014-06-11       Impact factor: 3.267

2.  Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents.

Authors:  Xueping Zhang; Kendra M Haney; Amanda C Richardson; Eden Wilson; David A Gewirtz; Joy L Ware; Zendra E Zehner; Yan Zhang
Journal:  Bioorg Med Chem Lett       Date:  2010-06-08       Impact factor: 2.823

3.  Anibamine and Its Analogues: Potent Antiplasmodial Agents from Aniba citrifolia.

Authors:  Yongle Du; Ana Lisa Valenciano; Yumin Dai; Yi Zheng; Feng Zhang; Yan Zhang; Jason Clement; Michael Goetz; David G I Kingston; Maria B Cassera
Journal:  J Nat Prod       Date:  2019-10-02       Impact factor: 4.050

4.  Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers.

Authors:  Feng Zhang; Saheem Zaidi; Kendra M Haney; Glen E Kellogg; Yan Zhang
Journal:  J Org Chem       Date:  2011-09-13       Impact factor: 4.354

5.  Development of methodologies for the regioselective synthesis of four series of regioisomer isoxazoles from β-enamino diketones.

Authors:  Raí G M Silva; Michael J V da Silva; Andrey P Jacomini; Sidnei Moura; Davi F Back; Ernani A Basso; Fernanda A Rosa
Journal:  RSC Adv       Date:  2018-01-25       Impact factor: 4.036

6.  Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models.

Authors:  Guo Li; Kendra M Haney; Glen E Kellogg; Yan Zhang
Journal:  J Chem Inf Model       Date:  2009-01       Impact factor: 4.956

7.  Efficient synthesis of β-enaminones and β-enaminoesters catalyzed by gold (I)/silver (I) under solvent-free conditions.

Authors:  Ming Zhang; Ablimit Abdukader; Yong Fu; Chengjian Zhu
Journal:  Molecules       Date:  2012-03-06       Impact factor: 4.411

8.  Structural tuning enables piezochromic and photochemical properties in N-aryl-β-enaminones.

Authors:  Wan-Chi Hsieh; Kiran B Manjappa; Ding-Yah Yang
Journal:  RSC Adv       Date:  2019-10-23       Impact factor: 4.036
  8 in total

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