OBJECTIVE: To examine age-related changes in the neural systems for reading in nonimpaired and dyslexic children and adolescents. METHODS: Functional magnetic resonance imaging was used to study age-related changes in the neural systems for reading in a cross-sectional sample of 232 right-handed children 7 to 18 years of age (113 dyslexic readers and 119 nonimpaired readers) as they read pseudowords. RESULTS: In nonimpaired readers, systems in the left anterior lateral occipitotemporal area developed with age, whereas systems in the right superior and middle frontal regions decreased. In contrast, in dyslexic readers, systems in the left posterior medial occipitotemporal regions developed with age. Older nonimpaired readers were left lateralized in the anterior lateral occipitotemporal area; there was no difference in asymmetry between younger and older dyslexic readers. INTERPRETATION: These findings offer a possible neurobiological explanation for the differences in reading acquisition between dyslexic and nonimpaired readers and provide further evidence of the critical role of the left occipitotemporal region in the development of reading.
OBJECTIVE: To examine age-related changes in the neural systems for reading in nonimpaired and dyslexic children and adolescents. METHODS: Functional magnetic resonance imaging was used to study age-related changes in the neural systems for reading in a cross-sectional sample of 232 right-handed children 7 to 18 years of age (113 dyslexic readers and 119 nonimpaired readers) as they read pseudowords. RESULTS: In nonimpaired readers, systems in the left anterior lateral occipitotemporal area developed with age, whereas systems in the right superior and middle frontal regions decreased. In contrast, in dyslexic readers, systems in the left posterior medial occipitotemporal regions developed with age. Older nonimpaired readers were left lateralized in the anterior lateral occipitotemporal area; there was no difference in asymmetry between younger and older dyslexic readers. INTERPRETATION: These findings offer a possible neurobiological explanation for the differences in reading acquisition between dyslexic and nonimpaired readers and provide further evidence of the critical role of the left occipitotemporal region in the development of reading.
Authors: Shawna L Palmer; Wilburn E Reddick; John O Glass; Robert Ogg; Zoltan Patay; Dana Wallace; Amar Gajjar Journal: Brain Imaging Behav Date: 2010-06 Impact factor: 3.978
Authors: Jennifer Lynn Bruno; Allison Zumberge; Franklin R Manis; Zhong-Lin Lu; Jason G Goldman Journal: Neuroimage Date: 2007-11-12 Impact factor: 6.556
Authors: Prasanna R Karunanayaka; Scott K Holland; Weihong Yuan; Mekibib Altaye; Blaise V Jones; Linda J Michaud; Nicolay Chertkoff Walz; Shari L Wade Journal: NeuroRehabilitation Date: 2007 Impact factor: 2.138
Authors: Richard E Frye; Khader Hasan; Lian Xue; David Strickland; Benjamin Malmberg; Jacqueline Liederman; Andrew Papanicolaou Journal: Neuroreport Date: 2008-10-29 Impact factor: 1.837
Authors: Elisabeth A Wilde; Stephen R McCauley; Zili Chu; Jill V Hunter; Erin D Bigler; Ragini Yallampalli; Zhiyue J Wang; Gerri Hanten; Xiaoqi Li; Marco A Ramos; Sharjeel H Sabir; Ana C Vasquez; Deleene Menefee; Harvey S Levin Journal: J Clin Exp Neuropsychol Date: 2008-12-03 Impact factor: 2.475