AIMS: To evaluate the relation between high methadone doses and methadone serum levels in MMT patients. DESIGN: One hundred fifty-one steady methadone-dose patients were evaluated for methadone serum levels using GCMS. Urine samples during the month prior to the study-day were analysed and defined as positive if any sample was positive for any drug. FINDINGS: Methadone dose correlated with methadone serum levels (Pearson R = 0.36, P < 0.0005). In 53 patients with no drug abuse, correlation was stronger (R = 0.53, P < 0.0005) than in 98 patients with any drug abuse (R = 0.25, P = 0.01). CONCLUSIONS: We extended the well-established correlation between methadone doses and serum levels in patients receiving low or moderate (60 to 120 mg/day) to high methadone doses (up to 290 mg/day).
AIMS: To evaluate the relation between high methadone doses and methadone serum levels in MMTpatients. DESIGN: One hundred fifty-one steady methadone-dose patients were evaluated for methadone serum levels using GCMS. Urine samples during the month prior to the study-day were analysed and defined as positive if any sample was positive for any drug. FINDINGS:Methadone dose correlated with methadone serum levels (Pearson R = 0.36, P < 0.0005). In 53 patients with no drug abuse, correlation was stronger (R = 0.53, P < 0.0005) than in 98 patients with any drug abuse (R = 0.25, P = 0.01). CONCLUSIONS: We extended the well-established correlation between methadone doses and serum levels in patients receiving low or moderate (60 to 120 mg/day) to high methadone doses (up to 290 mg/day).
Authors: M J Kreek; S D Schlussman; B Reed; Y Zhang; D A Nielsen; O Levran; Y Zhou; E R Butelman Journal: Neuropharmacology Date: 2008-08-07 Impact factor: 5.250
Authors: O Levran; E Peles; S Hamon; M Randesi; C Zhao; B Zhang; M Adelson; M J Kreek Journal: Pharmacogenomics J Date: 2011-03-01 Impact factor: 3.550