Literature DB >> 17438042

Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii.

Alessia Bertini1, Laurent Poirel, Sandrine Bernabeu, Daniela Fortini, Laura Villa, Patrice Nordmann, Alessandra Carattoli.   

Abstract

The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene bla(OXA-58) but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the bla(OXA-58) gene showed genetic variability, with the presence in several isolates of multiple copies of the bla(OXA-58) gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process.

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Year:  2007        PMID： 17438042      PMCID： PMC1913244          DOI： 10.1128/AAC.01502-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

1.  IMP-1 carbapenemase detected in an Acinetobacter clinical isolate from the UK.

Authors:  Luke Tysall; Mark W Stockdale; Paul R Chadwick; Marie-France I Palepou; Kevin J Towner; David M Livermore; Neil Woodford
Journal:  J Antimicrob Chemother       Date:  2002-01       Impact factor: 5.790

2.  Structure and mode of transposition of Tn2555 carrying sucrose utilization genes.

Authors:  Vera G Doroshenko; Vitaliy A Livshits
Journal:  FEMS Microbiol Lett       Date:  2004-04-15       Impact factor: 2.742

3.  bla(SHV) Genes in Klebsiella pneumoniae: different allele distributions are associated with different promoters within individual isolates.

Authors:  David S Hammond; Jacqueline M Schooneveldt; Graeme R Nimmo; Flavia Huygens; Philip M Giffard
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

4.  OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.

Authors:  Laurent Poirel; Sophie Marqué; Claire Héritier; Christine Segonds; Gérard Chabanon; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

5.  Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999).

Authors:  A C Gales; R N Jones; K R Forward; J Liñares; H S Sader; J Verhoef
Journal:  Clin Infect Dis       Date:  2001-05-15       Impact factor: 9.079

6.  Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonisation and infection.

Authors:  M del Mar Tomas; M Cartelle; S Pertega; A Beceiro; P Llinares; D Canle; F Molina; R Villanueva; J M Cisneros; G Bou
Journal:  Clin Microbiol Infect       Date:  2005-07       Impact factor: 8.067

7.  Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.

Authors:  M L Riccio; N Franceschini; L Boschi; B Caravelli; G Cornaglia; R Fontana; G Amicosante; G M Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

8.  Cloning, sequence analyses, expression, and distribution of ampC-ampR from Morganella morganii clinical isolates.

Authors:  L Poirel; M Guibert; D Girlich; T Naas; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

9.  Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testing.

Authors:  Timothy R Walsh; Anne Bolmström; Anette Qwärnström; Ana Gales
Journal:  J Clin Microbiol       Date:  2002-08       Impact factor: 5.948

10.  Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance.

Authors:  Raffaele Zarrilli; Margherita Crispino; Maria Bagattini; Elena Barretta; Anna Di Popolo; Maria Triassi; Paolo Villari
Journal:  J Clin Microbiol       Date:  2004-03       Impact factor: 5.948
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  47 in total

1.  Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii.

Authors:  Mark D Adams; E Ricky Chan; Neil D Molyneaux; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2010-06-07       Impact factor: 5.191

2.  Complete Sequences of Multidrug Resistance Plasmids Bearing rmtD1 and rmtD2 16S rRNA Methyltransferase Genes.

Authors:  Maria Fernanda C Bueno; Gabriela R Francisco; Doroti de Oliveira Garcia; Yohei Doi
Journal:  Antimicrob Agents Chemother       Date:  2016-01-04       Impact factor: 5.191

3.  Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimurium.

Authors:  Song Sun; Otto G Berg; John R Roth; Dan I Andersson
Journal:  Genetics       Date:  2009-05-27       Impact factor: 4.562

4.  Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program.

Authors:  Rodrigo E Mendes; Jan M Bell; John D Turnidge; Mariana Castanheira; Lalitagauri M Deshpande; Ronald N Jones
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191

Review 5.  Bacterial gene amplification: implications for the evolution of antibiotic resistance.

Authors:  Linus Sandegren; Dan I Andersson
Journal:  Nat Rev Microbiol       Date:  2009-08       Impact factor: 60.633

6.  Epidemiology and resistance features of Acinetobacter baumannii isolates from the ward environment and patients in the burn ICU of a Chinese hospital.

Authors:  Yali Gong; Xiaodong Shen; Guangtao Huang; Cheng Zhang; Xiaoqiang Luo; Supeng Yin; Jing Wang; Fuquan Hu; Yizhi Peng; Ming Li
Journal:  J Microbiol       Date:  2016-08-02       Impact factor: 3.422

7.  Evidence of diversity among epidemiologically related carbapenemase-producing Acinetobacter baumannii strains belonging to international clonal lineage II.

Authors:  Fabrizia Minandri; Silvia D'Arezzo; Luísa C S Antunes; Christine Pourcel; Luigi Principe; Nicola Petrosillo; Paolo Visca
Journal:  J Clin Microbiol       Date:  2012-01-11       Impact factor: 5.948

8.  Molecular characterization of acinetobacter isolates collected in intensive care units of six hospitals in Florence, Italy, during a 3-year surveillance program: a population structure analysis.

Authors:  Francesca Donnarumma; Simona Sergi; Cristina Indorato; Giorgio Mastromei; Roberto Monnanni; Pieluigi Nicoletti; Patrizia Pecile; Daniela Cecconi; Roberta Mannino; Sara Bencini; Rosa Fanci; Alberto Bosi; Enrico Casalone
Journal:  J Clin Microbiol       Date:  2010-02-24       Impact factor: 5.948

9.  Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.

Authors:  Laurent Poirel; Wejdene Mansour; Olfa Bouallegue; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2008-02-25       Impact factor: 5.191

10.  Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii.

Authors:  Te-Li Chen; Roy Chen-Chih Wu; Men-Fang Shaio; Chang-Phone Fung; Wen-Long Cho
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191
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