Literature DB >> 1743778

Is calcium excess in western diet a major cause of arterial disease?

S Seely.   

Abstract

The daily requirement of a young adult for calcium is 300-400 mg, the quantity consumed in many third-world countries. The dietary intake can be doubled or trebled by consumption of milk, thus half a litre of milk, consumed by many individuals daily in prosperous countries, adds 600 mg. The need for calcium is greatly reduced in old age, so that the excess from a given intake becomes more pronounced. The potential hazard of a high intake is that a small fraction finds its way into soft tissues. The aorta is notably prone to calcification, resulting in loss of elasticity. The aorta and its large branches constitute an elastic reservoir, distended during systole and contracting in diastole. This contraction provides the energy for the maintenance of diastolic pressure, which decreases with the deterioration of elasticity and needs a continually increasing systolic pressure to restore its normal value. The heart is disadvantaged in two ways. Its work is increased by having to eject the systolic volume into a stiffer reservoir, and the diastolic filling of the coronary arteries is reduced. This is the main cause of hypertension in old age--there is no increase in blood pressure with age in undeveloped countries where intake of calcium is low. The best cure would be prevention: the reduction of intake of calcium in prosperous countries. Failing that, phytic acid is suggested as the best calcium antagonist. Phytic acid, a natural product present in grains, converts dietary calcium into insoluble phosphates which pass unabsorbed through the digestive tract. The presently used calcium antagonists are not so satisfactory.

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Year:  1991        PMID: 1743778     DOI: 10.1016/0167-5273(91)90346-q

Source DB:  PubMed          Journal:  Int J Cardiol        ISSN: 0167-5273            Impact factor:   4.164


  8 in total

Review 1.  The role of calcium in the prevention of cardiovascular disease--a review of observational studies and randomized clinical trials.

Authors:  Susanne Rautiainen; Lu Wang; JoAnn E Manson; Howard D Sesso
Journal:  Curr Atheroscler Rep       Date:  2013-11       Impact factor: 5.113

Review 2.  Calcium intake and risk of cardiovascular disease: a review of prospective studies and randomized clinical trials.

Authors:  Lu Wang; JoAnn E Manson; Howard D Sesso
Journal:  Am J Cardiovasc Drugs       Date:  2012-04-01       Impact factor: 3.571

Review 3.  Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health.

Authors:  Katarzyna Maresz
Journal:  Integr Med (Encinitas)       Date:  2015-02

4.  The Relationship Between Menopause and Metabolic Syndrome: Experimental and Bioinformatics Analysis.

Authors:  Abir Jaballah; Ismael Soltani; Wael Bahia; Azza Dandana; Yosra Hasni; Abdelhedi Miled; Salima Ferchichi
Journal:  Biochem Genet       Date:  2021-05-10       Impact factor: 1.890

5.  Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies.

Authors:  Xia Wang; Hongxia Chen; Yingying Ouyang; Jun Liu; Gang Zhao; Wei Bao; Maosheng Yan
Journal:  BMC Med       Date:  2014-09-25       Impact factor: 8.775

6.  Nutrient contents predict the bamboo-leaf-based diet of Assamese macaques living in limestone forests of southwest Guangxi, China.

Authors:  Yuhui Li; Guangzhi Ma; Qihai Zhou; Youbang Li; Zhonghao Huang
Journal:  Ecol Evol       Date:  2020-04-28       Impact factor: 2.912

7.  Assessing Causality in Associations of Serum Calcium and Magnesium Levels With Heart Failure: A Two-Sample Mendelian Randomization Study.

Authors:  Emilie Helte; Agneta Åkesson; Susanna C Larsson
Journal:  Front Genet       Date:  2019-10-23       Impact factor: 4.599

8.  Concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and biochemical parameters in adults with chronic heart failure.

Authors:  Iwona Gorący; Ewa Rębacz-Maron; Jan Korbecki; Jarosław Gorący
Journal:  PeerJ       Date:  2021-11-01       Impact factor: 2.984

  8 in total

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