Literature DB >> 17435322

Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis.

Venil N Sumantran1, Asavari Kulkarni, Sanjay Boddul, Trushna Chinchwade, Soumya J Koppikar, Abhay Harsulkar, Bhushan Patwardhan, Arvind Chopra, Ulhas V Wagh.   

Abstract

This is the first report describing two novel chondroprotective activities of aqueous extracts of Withania somnifera root powder.First,these extracts had a statistically significant,short-term chondroprotective effect on damaged human osteoarthritic cartilage matrix in 50% of the patients tested. Second,these extracts caused a significant and reproducible inhibition of the gelatinase activity of collagenase type 2 enzyme in vitro.

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Year:  2007        PMID： 17435322     DOI： 10.1007/s12038-007-0030-3

Source DB:  PubMed          Journal:  J Biosci        ISSN： 0250-5991            Impact factor:   1.826


  11 in total

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