Literature DB >> 17434491

Gene expression signatures in the newt irises during lens regeneration.

Evgeny Makarev1, Mindy K Call, Matthew W Grogg, Donald L Atkinson, Brett Milash, Shannon J Odelberg, Panagiotis A Tsonis.   

Abstract

Lens regeneration in adult newts is possible by transdifferentiation of the pigment epithelial cells (PECs) of the dorsal iris. The same cells in the ventral iris are not capable of such a process. To understand this difference in regenerative competency, we examined gene expression of 373 genes in the intact dorsal and ventral irises as well as in irises during the process of lens regeneration. We found similar signatures of gene expression in dorsal and ventral with several cases of even higher levels in the ventral iris. Such transcriptional activity in the regeneration-incompetent ventral iris was unexpected and calls for a revision of our views about mechanisms of lens regeneration induction.

Mesh：

Year:  2007        PMID： 17434491      PMCID： PMC1941784          DOI： 10.1016/j.febslet.2007.03.082

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  A new mathematical model for relative quantification in real-time RT-PCR.

Authors:  M W Pfaffl
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

2.  Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data.

Authors:  Christian Ramakers; Jan M Ruijter; Ronald H Lekanne Deprez; Antoon F M Moorman
Journal:  Neurosci Lett       Date:  2003-03-13       Impact factor: 3.046

Review 3.  Lens and retina regeneration: transdifferentiation, stem cells and clinical applications.

Authors:  Panagiotis A Tsonis; Katia Del Rio-Tsonis
Journal:  Exp Eye Res       Date:  2004-02       Impact factor: 3.467

Review 4.  Eye regeneration at the molecular age.

Authors:  Katia Del Rio-Tsonis; Panagiotis A Tsonis
Journal:  Dev Dyn       Date:  2003-02       Impact factor: 3.780

5.  Tissue inhibitor of metalloproteinase 1 regulates matrix metalloproteinase activity during newt limb regeneration.

Authors:  Tamara J Stevenson; Vladimir Vinarsky; Donald L Atkinson; Mark T Keating; Shannon J Odelberg
Journal:  Dev Dyn       Date:  2006-03       Impact factor: 3.780

6.  Cellular electroporation induces dedifferentiation in intact newt limbs.

Authors:  Donald L Atkinson; Tamara J Stevenson; Eon Joo Park; Matthew D Riedy; Brett Milash; Shannon J Odelberg
Journal:  Dev Biol       Date:  2006-07-29       Impact factor: 3.582

Review 7.  Bridging the regeneration gap: genetic insights from diverse animal models.

Authors:  Alejandro Sánchez Alvarado; Panagiotis A Tsonis
Journal:  Nat Rev Genet       Date:  2006-11       Impact factor: 53.242

8.  BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration.

Authors:  Matthew W Grogg; Mindy K Call; Mitsumasa Okamoto; M Natalia Vergara; Katia Del Rio-Tsonis; Panagiotis A Tsonis
Journal:  Nature       Date:  2005-12-08       Impact factor: 49.962

9.  Cellular analysis on localization of lens forming potency in the newt iris epithelium.

Authors:  G Eguchi; R Shingai
Journal:  Dev Growth Differ       Date:  1971-12       Impact factor: 2.053

10.  The role of Pax-6 in lens regeneration.

Authors:  Mayur Madhavan; Tracy L Haynes; Nicholas C Frisch; Mindy K Call; Craig M Minich; Panagiotis A Tsonis; Katia Del Rio-Tsonis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-26       Impact factor: 11.205
  10 in total
  16 in total

1.  Molecular and cellular aspects of amphibian lens regeneration.

Authors:  Jonathan J Henry; Panagiotis A Tsonis
Journal:  Prog Retin Eye Res       Date:  2010-07-16       Impact factor: 21.198

Review 2.  Cell signaling pathways in vertebrate lens regeneration.

Authors:  Jonathan J Henry; Alvin G Thomas; Paul W Hamilton; Lisa Moore; Kimberly J Perry
Journal:  Curr Top Microbiol Immunol       Date:  2013       Impact factor: 4.291

3.  miRNAs in newt lens regeneration: specific control of proliferation and evidence for miRNA networking.

Authors:  Kenta Nakamura; Nobuyasu Maki; Albert Trinh; Heidi W Trask; Jiang Gui; Craig R Tomlinson; Panagiotis A Tsonis
Journal:  PLoS One       Date:  2010-08-11       Impact factor: 3.240

4.  Expression of stem cell pluripotency factors during regeneration in newts.

Authors:  Nobuyasu Maki; Rinako Suetsugu-Maki; Hiroshi Tarui; Kiyokazu Agata; Katia Del Rio-Tsonis; Panagiotis A Tsonis
Journal:  Dev Dyn       Date:  2009-06       Impact factor: 3.780

Review 5.  Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis.

Authors:  Dimitrios C Mastellos; Robert A Deangelis; John D Lambris
Journal:  Semin Immunol       Date:  2013-05-17       Impact factor: 11.130

6.  A comparative proteomic analysis during urodele lens regeneration.

Authors:  Meagan Roddy; Timothy P Fox; Jonathan P McFadden; Kenta Nakamura; Katia Del Rio-Tsonis; Panagiotis A Tsonis
Journal:  Biochem Biophys Res Commun       Date:  2008-10-09       Impact factor: 3.575

7.  Gene expression profiles of lens regeneration and development in Xenopus laevis.

Authors:  Erica L Malloch; Kimberly J Perry; Lisa Fukui; Verity R Johnson; Jason Wever; Caroline W Beck; Michael W King; Jonathan J Henry
Journal:  Dev Dyn       Date:  2009-09       Impact factor: 3.780

8.  A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration.

Authors:  Sarah E Mercer; Shannon J Odelberg; Hans-Georg Simon
Journal:  Dev Biol       Date:  2013-08-11       Impact factor: 3.582

9.  MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt.

Authors:  Panagiotis A Tsonis; Mindy K Call; Matthew W Grogg; Maureen A Sartor; Ruth R Taylor; Andrew Forge; Robert Fyffe; Robert Goldenberg; Richard Cowper-Sal-lari; Craig R Tomlinson
Journal:  Biochem Biophys Res Commun       Date:  2007-08-27       Impact factor: 3.575

10.  A microarray analysis of gene expression patterns during early phases of newt lens regeneration.

Authors:  Konstantinos Sousounis; Christian S Michel; Marc Bruckskotten; Nobuyasu Maki; Thilo Borchardt; Thomas Braun; Mario Looso; Panagiotis A Tsonis
Journal:  Mol Vis       Date:  2013-01-28       Impact factor: 2.367
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