| Literature DB >> 17434304 |
Mark E Schnute1, David J Anderson, Roger J Brideau, Fred L Ciske, Sarah A Collier, Michele M Cudahy, MariJean Eggen, Michael J Genin, Todd A Hopkins, Thomas M Judge, Euibong J Kim, Mary L Knechtel, Sajiv K Nair, James A Nieman, Nancee L Oien, Allen Scott, Steven P Tanis, Valerie A Vaillancourt, Michael W Wathen, Janet L Wieber.
Abstract
A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.Entities:
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Year: 2007 PMID： 17434304 DOI： 10.1016/j.bmcl.2007.03.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823