| Literature DB >> 17433505 |
Andrew Scribner1, Richard Dennis, Jean Hong, Shuliang Lee, Donald McIntyre, David Perrey, Dennis Feng, Michael Fisher, Matthew Wyvratt, Penny Leavitt, Paul Liberator, Anne Gurnett, Chris Brown, John Mathew, Donald Thompson, Dennis Schmatz, Tesfaye Biftu.
Abstract
Coccidiosis is the major cause of morbidity and mortality in the poultry industry. Protozoan parasites of the genus Eimeria invade the intestinal lining of the avian host causing tissue pathology, poor weight gain, and in some cases mortality. Resistance to current anticoccidials has prompted the search for new therapeutic agents with potent in vitro and in vivo activity against Eimeria. Antiparasitic activity is due to inhibition of a parasite specific cGMP-dependent protein kinase (PKG). In this study, we present the synthesis and biological activity of imidazo[1,2-a]pyridine anticoccidial agents. From this series, several compounds showed subnanomolar in vitro activity and commercial levels of in vivo activity. However, the potential genotoxicity of these compounds precludes them from further development.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17433505 DOI： 10.1016/j.ejmech.2007.02.006
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514