Literature DB >> 17431704

Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease.

A Goris1, C H Williams-Gray, T Foltynie, J Brown, M Maranian, A Walton, D A S Compston, R A Barker, S J Sawcer.   

Abstract

Given the known roles of TGFbeta2 in both regulating the immune system and promoting the survival of dopaminergic neurons, it is feasible that genetic variations in TGFB2 might play an aetiological role in neurological diseases such as Multiple Sclerosis (MS) and Parkinson's disease (PD). Hence we performed an indirect association analysis of TGFB2 using 8 haplotype-tagging SNPs in a population of 937 MS patients, 538 PD cases and 2022 controls. We found no evidence for association with susceptibility or progression of MS, but have demonstrated a trend towards association of the 5' region of the gene with susceptibility to PD. Further analysis of TGFB2 is warranted in other PD cohorts.

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Year:  2007        PMID： 17431704     DOI： 10.1007/s00415-006-0414-6

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  11 in total

1.  Pedigree disequilibrium tests for multilocus haplotypes.

Authors:  Frank Dudbridge
Journal:  Genet Epidemiol       Date:  2003-09       Impact factor: 2.135

2.  Haploview: analysis and visualization of LD and haplotype maps.

Authors:  J C Barrett; B Fry; J Maller; M J Daly
Journal:  Bioinformatics       Date:  2004-08-05       Impact factor: 6.937

3.  A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.

Authors:  Dale R Nyholt
Journal:  Am J Hum Genet       Date:  2004-03-02       Impact factor: 11.025

Review 4.  Transforming growth factor-beta : biology and clinical relevance.

Authors:  Isaac Yi Kim; Moses M Kim; Seong-Jin Kim
Journal:  J Biochem Mol Biol       Date:  2005-01-31

5.  Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits.

Authors:  Zane B Andrews; Hua Zhao; Tony Frugier; Reiko Meguro; David R Grattan; Kyoko Koishi; Ian S McLennan
Journal:  Neurobiol Dis       Date:  2005-10-27       Impact factor: 5.996

6.  Lack of association of transforming growth factor (TGF)-beta 1 and beta 2 gene polymorphisms with multiple sclerosis (MS) in Northern Ireland.

Authors:  G V McDonnell; C W Kirk; S A Hawkins; C A Graham
Journal:  Mult Scler       Date:  1999-04       Impact factor: 6.312

7.  Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity.

Authors:  R H S R Roxburgh; S R Seaman; T Masterman; A E Hensiek; S J Sawcer; S Vukusic; I Achiti; C Confavreux; M Coustans; E le Page; G Edan; G V McDonnell; S Hawkins; M Trojano; M Liguori; E Cocco; M G Marrosu; F Tesser; M A Leone; A Weber; F Zipp; B Miterski; J T Epplen; A Oturai; P Soelberg Sørensen; E G Celius; N Téllez Lara; X Montalban; P Villoslada; A M Silva; M Marta; I Leite; B Dubois; J Rubio; H Butzkueven; T Kilpatrick; M P Mycko; K W Selmaj; M E Rio; M Sá; G Salemi; G Savettieri; J Hillert; D A S Compston
Journal:  Neurology       Date:  2005-04-12       Impact factor: 9.910

8.  The effects of transforming growth factor-beta2 on dopaminergic graft survival.

Authors:  Shannon L Macauley; Alexander D Horsch; Marinus Oterdoom; Ming H Zheng; Gregory R Stewart
Journal:  Cell Transplant       Date:  2004       Impact factor: 4.064

9.  TGF-beta promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8.

Authors:  Eleni Roussa; Lilla M Farkas; Kerstin Krieglstein
Journal:  Neurobiol Dis       Date:  2004-07       Impact factor: 5.996

10.  Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis.

Authors:  B He; C Xu; B Yang; A M Landtblom; S Fredrikson; J Hillert
Journal:  J Neuroimmunol       Date:  1998-06-01       Impact factor: 3.478
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  9 in total

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Authors:  Sitt Wai Fong; Ian S McLennan; Andrew McIntyre; Jayne Reid; Kathleen I J Shennan; Guy S Bewick
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

Review 2.  Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives.

Authors:  Jesse V Veenvliet; Marten P Smidt
Journal:  Cell Mol Life Sci       Date:  2014-07-27       Impact factor: 9.261

Review 3.  The role of TGF-β superfamily signaling in neurological disorders.

Authors:  Risa Kashima; Akiko Hata
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2018-01-01       Impact factor: 3.848

4.  Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice.

Authors:  Ina Tesseur; Andy Nguyen; Betty Chang; Lulin Li; Nathaniel S Woodling; Tony Wyss-Coray; Jian Luo
Journal:  J Neurosci       Date:  2017-03-31       Impact factor: 6.167

5.  Region-specific protein abundance changes in the brain of MPTP-induced Parkinson's disease mouse model.

Authors:  Xu Zhang; Jian-Ying Zhou; Mark H Chin; Athena A Schepmoes; Vladislav A Petyuk; Karl K Weitz; Brianne O Petritis; Matthew E Monroe; David G Camp; Stephen A Wood; William P Melega; Diana J Bigelow; Desmond J Smith; Wei-Jun Qian; Richard D Smith
Journal:  J Proteome Res       Date:  2010-03-05       Impact factor: 4.466

Review 6.  TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications.

Authors:  Jian Luo
Journal:  Biomedicines       Date:  2022-05-23

7.  The neuroprotective functions of transforming growth factor beta proteins.

Authors:  Arpád Dobolyi; Csilla Vincze; Gabriella Pál; Gábor Lovas
Journal:  Int J Mol Sci       Date:  2012-07-03       Impact factor: 6.208

Review 8.  TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease.

Authors:  Mª Dolores Muñoz; Nerea de la Fuente; Amelia Sánchez-Capelo
Journal:  Int J Mol Sci       Date:  2020-01-16       Impact factor: 5.923

9.  Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis.

Authors:  Maria L Elkjaer; Tobias Frisch; Richard Reynolds; Tim Kacprowski; Mark Burton; Torben A Kruse; Mads Thomassen; Jan Baumbach; Zsolt Illes
Journal:  Acta Neuropathol Commun       Date:  2019-12-11       Impact factor: 7.801
  9 in total

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