Literature DB >> 17429488

Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosa.

Abhiram S Vilupuru1, Nalini V Rangaswamy, Laura J Frishman, Earl L Smith, Ronald S Harwerth, Austin Roorda.   

Abstract

The lamina cribrosa has been postulated from in vitro studies as an early site of damage in glaucoma. Prior in vivo measures of laminar morphology have been confounded by ocular aberrations. In this study the lamina cribrosa was imaged after correcting for ocular aberrations using the adaptive optics scanning laser ophthalmoscope (AOSLO) in normal and glaucomatous eyes of rhesus monkeys. All measured laminar morphological parameters showed increased magnitudes in glaucomatous eyes relative to fellow control eyes, indicating altered structure. The AOSLO provides high-quality images of the lamina cribrosa and may have potential as a tool for early identification of glaucoma.

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Year:  2007        PMID： 17429488      PMCID： PMC4696388          DOI： 10.1364/josaa.24.001417

Source DB:  PubMed          Journal:  J Opt Soc Am A Opt Image Sci Vis        ISSN： 1084-7529            Impact factor:   2.129


  47 in total

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