Literature DB >> 17428856

New structure model for the packaging signal in the genome of group IIa coronaviruses.

Shih-Cheng Chen1, Erwin van den Born, Sjoerd H E van den Worm, Cornelis W A Pleij, Eric J Snijder, René C L Olsthoorn.   

Abstract

A 190-nucleotide (nt) packaging signal (PS) located in the 3' end of open reading frame 1b in the mouse hepatitis virus, a group IIa coronavirus, was previously postulated to direct genome RNA packaging. Based on phylogenetic data and structure probing, we have identified a 95-nt hairpin within the 190-nt PS domain which is conserved in all group IIa coronaviruses but not in the severe acute respiratory syndrome coronavirus (group IIb), group I coronaviruses, or group III coronaviruses. The hairpin is composed of six copies of a repeating structural subunit that consists of 2-nt bulges and 5-bp stems. We propose that repeating AA bulges are characteristic features of group IIa PSs.

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Year:  2007        PMID： 17428856      PMCID： PMC1900089          DOI： 10.1128/JVI.02231-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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Journal:  MBio       Date:  2018-05-01       Impact factor: 7.867
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