Literature DB >> 17428115

Infantile scurvy: an old diagnosis revisited with a modern dietary twist.

Cynthia J Burk1, Rona Molodow.   

Abstract

Ascorbic acid (vitamin C) is necessary for the formation of collagen, reducing free radicals, and aiding in iron absorption. Scurvy, a disease of dietary ascorbic acid deficiency, is uncommon today. Indeed, implementation of dietary recommendations largely eradicated infantile scurvy in the US in the early 1900s. We present a case of an otherwise healthy 2-year-old Caucasian girl who presented with refusal to walk secondary to pain in her lower extremities, generalized irritability, sleep disturbance, and malaise. The girl's parents described feeding the patient an organic diet recommended by the Church of Scientology that included a boiled mixture of organic whole milk, barley, and corn syrup devoid of fruits and vegetables. Physical examination revealed pale, bloated skin with edematous, violaceous gums and loosening of a few of her teeth. Dermatologic findings included xerosis, multiple scattered ecchymoses of the extremities, and perifollicular hemorrhage. Laboratory and radiographic evaluation confirmed the diagnosis of scurvy. The patient showed dramatic improvement after only 3 days of treatment with oral ascorbic acid and significant dietary modification. In this case report, we revisit the old diagnosis of scurvy with a modern dietary twist secondary to religious practices. This case highlights the importance of taking a detailed dietary history when evaluating diseases involving the skin.

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Year:  2007        PMID: 17428115     DOI: 10.2165/00128071-200708020-00006

Source DB:  PubMed          Journal:  Am J Clin Dermatol        ISSN: 1175-0561            Impact factor:   7.403


  7 in total

1.  Severe vitamin C deficiency in a child newly diagnosed with T-cell ALL due to nutrient gap.

Authors:  Sydney Harris-Janz; Donna Johnston; Jacqueline Halton
Journal:  BMJ Case Rep       Date:  2016-01-28

2.  Infantile scurvy: two case reports.

Authors:  Leila Ghedira Besbes; Samir Haddad; Chebil Ben Meriem; Mondher Golli; Mohamed-Fadhel Najjar; Mohamed-Néji Guediche
Journal:  Int J Pediatr       Date:  2010-09-29

3.  Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C.

Authors:  Yan Jiao; Jifei Zhang; Jian Yan; John Stuart; Griffin Gibson; Lu Lu; Robert Willaims; Yong Jun Wang; Weikuan Gu
Journal:  Genet Mol Biol       Date:  2011-07-01       Impact factor: 1.771

4.  Headband sign on magnetic resonance imaging: An unusual finding of scurvy in a 5-year-old child described first time.

Authors:  Umesh I Patel; Jayendra R Gohil; Alpa N Parekh; Hardik R Chauhan
Journal:  J Pediatr Neurosci       Date:  2016 Oct-Dec

5.  Comparative analysis of ascorbic acid in human milk and infant formula using varied milk delivery systems.

Authors:  Jimi Francis; Kristy Rogers; Paul Brewer; Darby Dickton; Ron Pardini
Journal:  Int Breastfeed J       Date:  2008-08-11       Impact factor: 3.461

Review 6.  Macroscopic features of scurvy in human skeletal remains: A literature synthesis and diagnostic guide.

Authors:  Anne Marie E Snoddy; Hallie R Buckley; Gail E Elliott; Vivien G Standen; Bernardo T Arriaza; Siân E Halcrow
Journal:  Am J Phys Anthropol       Date:  2018-10-09       Impact factor: 2.868

Review 7.  A Narrative Review on Pediatric Scurvy: The Last Twenty Years.

Authors:  Sandra Trapani; Chiara Rubino; Giuseppe Indolfi; Paolo Lionetti
Journal:  Nutrients       Date:  2022-02-06       Impact factor: 5.717

  7 in total

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