Literature DB >> 17425917

Insights on pathogenesis of type 2 diabetes from MODY genetics.

Michael N Weedon1, Timothy M Frayling.   

Abstract

Maturity-onset diabetes of the young (MODY) is a type of non-insulin-dependent diabetes mellitus caused by rare autosomal-dominant mutations. MODY genes play key biochemical roles in the pancreatic beta cell; therefore, common variants of MODY genes are excellent candidate genes for type 2 diabetes. We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes.

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Year:  2007        PMID： 17425917     DOI： 10.1007/s11892-007-0022-6

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   5.430


  69 in total

1.  MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1.

Authors:  S Y Kristinsson; E T Thorolfsdottir; B Talseth; E Steingrimsson; A V Thorsson; T Helgason; A B Hreidarsson; R Arngrimsson
Journal:  Diabetologia       Date:  2001-11       Impact factor: 10.122

2.  A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.

Authors:  Christian S Rose; Jakob Ek; Søren A Urhammer; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Journal:  Diabetes       Date:  2005-10       Impact factor: 9.461

3.  Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.

Authors:  Kazuo Hara; Momoko Horikoshi; Hiroji Kitazato; Chikako Ito; Mitsuhiko Noda; Jun Ohashi; Philippe Froguel; Katsushi Tokunaga; Kazuyuki Tobe; Ryozo Nagai; Takashi Kadowaki
Journal:  Diabetes       Date:  2006-05       Impact factor: 9.461

4.  IPF-1 gene variation and the development of type 2 diabetes.

Authors:  Kristi Silver; Archana Shetty
Journal:  Mol Genet Metab       Date:  2002-03       Impact factor: 4.797

5.  Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

Authors:  Michael N Weedon; Katharine R Owen; Beverley Shields; Graham Hitman; Mark Walker; Mark I McCarthy; Latisha D Love-Gregory; M Alan Permutt; Andrew T Hattersley; Timothy M Frayling
Journal:  Diabetes       Date:  2004-11       Impact factor: 9.461

6.  Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.

Authors:  D A Stoffers; N T Zinkin; V Stanojevic; W L Clarke; J F Habener
Journal:  Nat Genet       Date:  1997-01       Impact factor: 38.330

7.  Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

Authors:  K Yamagata; H Furuta; N Oda; P J Kaisaki; S Menzel; N J Cox; S S Fajans; S Signorini; M Stoffel; G I Bell
Journal:  Nature       Date:  1996-12-05       Impact factor: 49.962

8.  Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in caucasians.

Authors:  L Hansen; S Urioste; H V Petersen; J N Jensen; H Eiberg; F Barbetti; P Serup; T Hansen; O Pedersen
Journal:  J Clin Endocrinol Metab       Date:  2000-03       Impact factor: 5.958

9.  A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

Authors:  Michael N Weedon; Vanessa J Clark; Yudong Qian; Yoav Ben-Shlomo; Nicholas Timpson; Shah Ebrahim; Debbie A Lawlor; Marcus E Pembrey; Susan Ring; Terry J Wilkin; Linda D Voss; Alison N Jeffery; Brad Metcalf; Luigi Ferrucci; Anna Maria Corsi; Anna Murray; David Melzer; Bridget Knight; Bev Shields; George Davey Smith; Andrew T Hattersley; Anna Di Rienzo; Tim M Frayling
Journal:  Am J Hum Genet       Date:  2006-10-06       Impact factor: 11.025

10.  Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

Authors:  Michael N Weedon; Mark I McCarthy; Graham Hitman; Mark Walker; Christopher J Groves; Eleftheria Zeggini; N William Rayner; Beverley Shields; Katharine R Owen; Andrew T Hattersley; Timothy M Frayling
Journal:  PLoS Med       Date:  2006-10       Impact factor: 11.069
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  5 in total

1.  Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies.

Authors:  Lipika R Pal; John Moult
Journal:  J Mol Biol       Date:  2015-05-01       Impact factor: 5.469

Review 2.  Rare and common variants: twenty arguments.

Authors:  Greg Gibson
Journal:  Nat Rev Genet       Date:  2012-01-18       Impact factor: 53.242

3.  Genetic causes of maturity onset diabetes of the young may be less prevalent in American pregnant women recently diagnosed with diabetes mellitus than in previously studied European populations.

Authors:  M F Sewell; L H Presley; S H Holland; P M Catalano
Journal:  J Matern Fetal Neonatal Med       Date:  2014-07-30

4.  Complete complement deficiency in a large cohort of familial systemic lupus erythematosus.

Authors:  R Aggarwal; A L Sestak; A D'Souza; A D'Sousa; S P Dillon; B Namjou; R H Scofield
Journal:  Lupus       Date:  2009-11-12       Impact factor: 2.911

5.  Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.

Authors:  Nadia Tinto; Adriana Zagari; Marina Capuano; Alfonso De Simone; Valentina Capobianco; Gerardo Daniele; Michela Giugliano; Raffaella Spadaro; Adriana Franzese; Lucia Sacchetti
Journal:  PLoS One       Date:  2008-04-02       Impact factor: 3.240
  5 in total

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