Literature DB >> 17425544

Successful management of deep facial burns in a patient with extensive third-degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing.

Mario Marazzi1, Armando De Angelis, Adriano Ravizza, Marco N Ordanini, Leonarda Falcone, Anna Chiaratti, Francesca Crovato, Donata Calò, Silvio Veronese, Vincenzo Rapisarda.   

Abstract

Full-thickness burns of the face are notoriously difficult to repair and their management poses a series of problems to the surgeon. We present the case of a 49-year-old man (only survivor of a catastrophic airport accident) with third-degree flame burns to >80% of total body surface area and extensive face damage who achieved a fully satisfactory outcome after a treatment plan based on gradual escharectomy followed by application of artificial dermis and, later, grafting with sheets of cultured keratinocytes. Re-epithelialisation was already visible at day 16 after admission and all facial wounds were closed by day 56, the treatment continuing on the scalp. Within 6 months of the accident, the patient had recovered functional and cosmetic features (including re-growth of skin appendages) that were beyond expectations. The use of nanocrystalline silver-coated dressings during the escharectomy and resurfacing phases was important, as part of a multifaceted strategy, in ensuring excellent antimicrobial control, thus avoiding the need for autologous grafting and contributing to a rapid healing and complete restoration of the face and head skin.

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Year:  2007        PMID: 17425544      PMCID: PMC7951304          DOI: 10.1111/j.1742-481X.2006.00263.x

Source DB:  PubMed          Journal:  Int Wound J        ISSN: 1742-4801            Impact factor:   3.315


  20 in total

1.  The physiology of wound healing. A summary of normal and abnormal wound healing processes.

Authors:  H P Ehrlich
Journal:  Adv Wound Care       Date:  1998 Nov-Dec       Impact factor: 4.730

2.  Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing.

Authors:  J Barry Wright; Kan Lam; Andre G Buret; Merle E Olson; Robert E Burrell
Journal:  Wound Repair Regen       Date:  2002 May-Jun       Impact factor: 3.617

3.  The use of cultured autologous keratinocytes with integra in the resurfacing of acute burns.

Authors:  A N Pandya; B Woodward; N Parkhouse
Journal:  Plast Reconstr Surg       Date:  1998-09       Impact factor: 4.730

Review 4.  Cultured keratinocytes and keratinocyte grafts.

Authors:  K Hancock; I M Leigh
Journal:  BMJ       Date:  1989-11-11

5.  Inhibition of wound healing by antiseptics.

Authors:  R Niedner; E Schöpf
Journal:  Br J Dermatol       Date:  1986-08       Impact factor: 9.302

Review 6.  Topical agents in burn and wound care.

Authors:  R S Ward; J R Saffle
Journal:  Phys Ther       Date:  1995-06

7.  Efficacy of topical silver against fungal burn wound pathogens.

Authors:  J B Wright; K Lam; D Hansen; R E Burrell
Journal:  Am J Infect Control       Date:  1999-08       Impact factor: 2.918

8.  Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment.

Authors:  J B Wright; K Lam; R E Burrell
Journal:  Am J Infect Control       Date:  1998-12       Impact factor: 2.918

9.  Cytotoxicity of topical antimicrobial agents used in burn wounds in Australasia.

Authors:  John F Fraser; Leila Cuttle; Margit Kempf; Roy M Kimble
Journal:  ANZ J Surg       Date:  2004-03       Impact factor: 1.872

Review 10.  The changing epidemiology of infection in burn patients.

Authors:  B A Pruitt; A T McManus
Journal:  World J Surg       Date:  1992 Jan-Feb       Impact factor: 3.352

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  3 in total

1.  Skin substitutes based on allogenic fibroblasts or keratinocytes for chronic wounds not responding to conventional therapy: a retrospective observational study.

Authors:  Giorgio Pajardi; Vicenzo Rapisarda; Francesco Somalvico; Andrea Scotti; Giulia Lo Russo; Francesco Ciancio; Arturo Sgrò; Manuela Nebuloni; Raffaele Allevi; Maria L Torre; Emilio Trabucchi; Mario Marazzi
Journal:  Int Wound J       Date:  2014-02-12       Impact factor: 3.315

2.  Treatment of partial thickness burns of the face with Acticoat7™ : A retrospective single center study.

Authors:  Jakob Nedomansky; Alan Oramary; Stefanie Nickl; Gunther Fuchs; Christine Radtke; Werner Haslik; Alexandra Fochtmann-Frana
Journal:  Wien Klin Wochenschr       Date:  2020-10-30       Impact factor: 1.704

3.  Active silver nanoparticles for wound healing.

Authors:  Chiara Rigo; Letizia Ferroni; Ilaria Tocco; Marco Roman; Ivan Munivrana; Chiara Gardin; Warren R L Cairns; Vincenzo Vindigni; Bruno Azzena; Carlo Barbante; Barbara Zavan
Journal:  Int J Mol Sci       Date:  2013-03-01       Impact factor: 5.923

  3 in total

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