BACKGROUND: Fungal infections of burn wounds have become an important cause of burn-associated morbidity and mortality. The nature of fungal infections dictates aggressive treatment to minimize the morbidity associated with these infections. Persons with large total body surface area burns are particularly susceptible to fungal infections and are treated in such a manner as to minimize their risk of infection. METHODS: This study examined the in vitro fungicidal efficacy of a variety of different topical agents. By placing fungal inocula in contact with mafenide acetate, silver nitrate, silver sulfadiazine, and a nanocrystalline silver-coated dressing, we determined the kill kinetics of these topical agents against a spectrum of common burn wound fungal pathogens. RESULTS: The topical antimicrobials that were tested demonstrated varying degrees of efficacy against these pathogens. CONCLUSION: The nanocrystalline silver-based dressing provided the fastest and broadest-spectrum fungicidal activity and may make it a good candidate for use to minimize the potential of fungal infection, thereby reducing complications that delay wound healing.
BACKGROUND:Fungal infections of burn wounds have become an important cause of burn-associated morbidity and mortality. The nature of fungal infections dictates aggressive treatment to minimize the morbidity associated with these infections. Persons with large total body surface area burns are particularly susceptible to fungal infections and are treated in such a manner as to minimize their risk of infection. METHODS: This study examined the in vitro fungicidal efficacy of a variety of different topical agents. By placing fungal inocula in contact with mafenide acetate, silver nitrate, silver sulfadiazine, and a nanocrystalline silver-coated dressing, we determined the kill kinetics of these topical agents against a spectrum of common burn wound fungal pathogens. RESULTS: The topical antimicrobials that were tested demonstrated varying degrees of efficacy against these pathogens. CONCLUSION: The nanocrystalline silver-based dressing provided the fastest and broadest-spectrum fungicidal activity and may make it a good candidate for use to minimize the potential of fungal infection, thereby reducing complications that delay wound healing.
Authors: Ranjith Babu; Jianying Zhang; Eric J Beckman; Mohammed Virji; William A Pasculle; Alan Wells Journal: Biomaterials Date: 2006-04-24 Impact factor: 12.479
Authors: Maggie Herron; Ankit Agarwal; Patricia R Kierski; Diego F Calderon; Leandro B C Teixeira; Michael J Schurr; Christopher J Murphy; Charles J Czuprynski; Jonathan F McAnulty; Nicholas L Abbott Journal: Adv Healthc Mater Date: 2014-02-12 Impact factor: 9.933
Authors: Amir Ibrahim; Shawn Fagan; Tim Keaney; Karim A Sarhane; Derek A Hursey; Philip Chang; Rob Sheridan; Colleen Ryan; Ronald Tompkins; Jeremy Goverman Journal: J Burn Care Res Date: 2014 Jul-Aug Impact factor: 1.845