| Literature DB >> 17420124 |
Takumi Furuta1, Yasuo Hirooka, Ayako Abe, Yusuke Sugata, Mitsuru Ueda, Kouki Murakami, Takashi Suzuki, Kiyoshi Tanaka, Toshiyuki Kan.
Abstract
Dideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG (1), was efficiently prepared by directly introducing a ketone group at C3 and successive reduction to the sec-alcohol with 2,3-cis stereochemistry. Compound 2 showed potent anti-influenza virus activity, indicating that the hydroxyl substituents on the A-ring are not crucial for anti-influenza virus activity.Entities:
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Year: 2007 PMID： 17420124 DOI： 10.1016/j.bmcl.2007.03.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823