Literature DB >> 17419064

A new class of nifuroxazide analogues: synthesis of 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus.

Andrea Masunari1, Leoberto Costa Tavares.   

Abstract

Hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) has been an increasing problem worldwide since the initial reports over 40 years ago. To examine new drug leads with potential antibacterial activities, 14 p-substituted benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazides were designed, synthesized, and tested against standard and multidrug-resistant S. aureus strains by serial dilution tests. All compounds exhibited significant bacteriostatic activity and some of them also showed bactericidal activity. The results confirmed the potential of this class of compounds as an alternative for the development of selective antimicrobial agents.

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Year:  2007        PMID： 17419064     DOI： 10.1016/j.bmc.2007.03.068

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  17 in total

1.  Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model.

Authors:  Ashish M Kanhed; Radha Charan Dash; Nishant Parmar; Tarun Kumar Das; Rajani Giridhar; Mange Ram Yadav
Journal:  Mol Divers       Date:  2015-07-17       Impact factor: 2.943

2.  Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

Authors:  Erik A Nelson; Sarah R Walker; Alicia Kepich; Laurie B Gashin; Teru Hideshima; Hiroshi Ikeda; Dharminder Chauhan; Kenneth C Anderson; David A Frank
Journal:  Blood       Date:  2008-09-29       Impact factor: 22.113

3.  2-Phenoxy-acetohydrazide.

Authors:  Hoong-Kun Fun; Ching Kheng Quah; Arun M Isloor; Dhanya Sunil; Prakash Shetty
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-04

Review 4.  Biological activities of hydrazone derivatives.

Authors:  Sevim Rollas; S Güniz Küçükgüzel
Journal:  Molecules       Date:  2007-08-17       Impact factor: 4.411

5.  Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.

Authors:  Liang Yang; Morten Theil Rybtke; Tim Holm Jakobsen; Morten Hentzer; Thomas Bjarnsholt; Michael Givskov; Tim Tolker-Nielsen
Journal:  Antimicrob Agents Chemother       Date:  2009-04-13       Impact factor: 5.191

6.  2-(2-Chloro-phen-oxy)acetohydrazide.

Authors:  Hoong-Kun Fun; Ching Kheng Quah; Arun M Isloor; Dhanya Sunil; Prakash Shetty
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-04

7.  2-Chloro-N-[4-(3-methyl-3-phenyl-cyclo-but-yl)-1,3-thia-zol-2-yl]-N'-(naphthalen-1-yl-methyl-idene)acetohydrazide.

Authors:  Ersin Inkaya; Muharrem Dinçer; Alaaddin Cukurovalı; Engin Yılmaz
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-08

8.  Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties.

Authors:  Olayinka O Ajani; Oluwole B Familoni; Feipeng Wu; Johnbull O Echeme; Zheng Sujiang
Journal:  Int J Med Chem       Date:  2012-10-17

9.  Synthesis of Oxadiazolyl, Pyrazolyl and Thiazolyl Derivatives of Thiophene-2-Carboxamide as Antimicrobial and Anti-HCV Agents.

Authors:  Ola H Rizk; Omaima G Shaaban; Abeer E Abdel Wahab
Journal:  Open Med Chem J       Date:  2017-04-28

10.  2-(2-Nitro-phen-yl)acetohydrazide.

Authors:  A S Praveen; Jerry P Jasinski; Amanda C Keeley; H S Yathirajan; B Narayana
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-24
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