Literature DB >> 17418445

Positive and negative selection on the mitochondrial genome.

Colin D Meiklejohn1, Kristi L Montooth, David M Rand.   

Abstract

Several recent studies have confirmed that mitochondrial DNA variation and evolution are not consistent with the neutral theory of molecular evolution and might be inappropriate for estimating effective population sizes. Evidence for the action of both positive and negative selection on mitochondrial genes has been put forward, and the complex genetics of mitochondrial DNA adds to the challenge of resolving this debate. The solution could lie in distinguishing genetic drift from 'genetic draft' and in dissecting the physiology of mitochondrial fitness.

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Year:  2007        PMID： 17418445     DOI： 10.1016/j.tig.2007.03.008

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  106 in total

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