| Literature DB >> 17418443 |
Peter H Thorpe1, Sergio González-Barrera, Rodney Rothstein.
Abstract
Polyploid cells are a characteristic feature of certain human tissues, and notably many cancers. In a systematic genomic screen in yeast, Storchová and co-workers identified the genetic requirements of tetraploidy. Surprisingly, they showed that only three connected pathways are essential for the viability of tetraploid yeast cells. These data provide exciting new targets that might be essential specifically in polyploid cancer cells.Entities:
Mesh：
Year: 2007 PMID： 17418443 DOI： 10.1016/j.tig.2007.03.016
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639